PMID- 18651386
OWN - NLM
STAT- MEDLINE
DCOM- 20081021
LR  - 20220316
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 15
IP  - 1
DP  - 2008
TI  - Predictive factors of myocardial reperfusion in patients with anterior wall acute 
      myocardial infarction.
PG  - 57-62
AB  - BACKGROUND: The no-reflow phenomenon due to microvasculature damage is sometimes 
      observed in patients despite patency of the infarct-related artery. The study 
      aimed to assess the predictive value of clinical, hemodynamic and 
      electrocardiographic parameters for the development of the no-reflow phenomenon 
      in patients after successful coronary reperfusion. METHODS: Eighty-six patients, 
      mean age 58.4 +/- 11.2, underwent primary percutaneous coronary intervention 
      (PCI) for acute anterior myocardial infarction (AMI). Angiographic parameters, 
      i.e. TIMI grade flow, cTFC, TMPG, wall motion score index (WMSI), ST-segment 
      resolution and segmental perfusion, were estimated by myocardial contrast 
      echocardiography (MCE). RESULTS: As evidenced by MCE, 54 patients were classified 
      as the reflow ones and 32 as no- reflow. Patients from the no-reflow group showed 
      a higher creatine kinase peak (p = 0.0034), higher kinase-MB (p = 0.0033) and 
      higher troponin level (p = 0.062), longer time span between the onset of pain and 
      reperfusion (p = 0.0003), worse baseline WMSI (p = 0.0022), inferior flow in the 
      infarct-related artery and ST-segment resolution. Univariate analysis revealed 
      that age, time span between the onset of chest pain to PCI, all angiographic 
      parameters, WMSI and ST-segment resolution were related to the no-reflow 
      phenomenon. Multivariate logistic regression analysis revealed that lack of 
      preservation of normal or nearnormal flow before PCI and significant impairment 
      of left ventricle contractility were independent predictive factors of the 
      no-reflow phenomenon. CONCLUSIONS: MCE yields vital information about the outcome 
      of coronary intervention in patients with AMI. Development of a no-reflow 
      phenomenon is correlated with the severity of myocardial damage and poor flow 
      through the infarct-related artery before PCI.
FAU - Olszowska, Maria
AU  - Olszowska M
AD  - Department of Cardiac and Vascular Diseases, Institute of Cardiology, 
      Jagiellonian University, Cracow, Poland. molszowska@szpitaljp2.krakow.pl
FAU - Tracz, Wieslawa
AU  - Tracz W
FAU - Kostkiewicz, Magdalena
AU  - Kostkiewicz M
FAU - Podolec, Piotr
AU  - Podolec P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
SB  - IM
CIN - Cardiol J. 2008;15(1):1-3. PMID: 18651378
MH  - Adult
MH  - Aged
MH  - *Angioplasty, Balloon, Coronary
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnostic imaging/*therapy
MH  - Myocardial Reperfusion
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
EDAT- 2008/07/25 09:00
MHDA- 2008/10/22 09:00
CRDT- 2008/07/25 09:00
PHST- 2008/07/25 09:00 [pubmed]
PHST- 2008/10/22 09:00 [medline]
PHST- 2008/07/25 09:00 [entrez]
PST - ppublish
SO  - Cardiol J. 2008;15(1):57-62.