PMID- 18651396
OWN - NLM
STAT- MEDLINE
DCOM- 20081022
LR  - 20080724
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 15
IP  - 2
DP  - 2008
TI  - Immunoglobulin E in patients with ischemic heart disease.
PG  - 122-8
AB  - BACKGROUND: In recent years, increased serum immunoglobulin E (IgE) concentration 
      in patients with cardiovascular diseases has been generating more and more 
      interest. It is as yet unknown, however, if the increased IgE level is a marker 
      of future coronary incidents and whether it may be regarded as an ischemic heart 
      disease risk factor, or if it is indicative of the participation of antibodies in 
      an inflammatory reaction to tissue damage. The aim of the study was to evaluate 
      what significant changes in the total IgE concentration occur in patients with 
      different forms of ischemic heart disease (IHD) and whether the concentration 
      differs in comparison to healthy people. Additionally, we evaluated the dynamics 
      of serum IgE concentration in patients with acute myocardial infarction. METHODS: 
      The study included 195 patients: 80 acute myocardial infarction (AMI) patients, 
      58 patients with troponin-negative acute coronary syndrome (ACS) and 57 patients 
      with stable angina pectoris, with negative personal and family history of 
      allergy. The control group consisted of 39 healthy, age-matched individuals. 
      Serum IgE concentration measurements were carried out with an Uni-cap Total IgE 
      kit, using the FEIA technique. RESULTS: In patients suffering from any form of 
      ischemic heart disease, significantly increased concentrations of serum 
      immunoglobulin E were found, as compared to the control group of healthy 
      individuals. Changes of IgE serum concentration on the 1(st) day, 7(th) day, 
      14(th) day and 40(th) day after AMI did not reveal any significant differences. 
      Males with AMI turned out to have significantly higher immunoglobulin 
      concentrations than females. CONCLUSION: The observed higher serum IgE 
      concentration in patients with IHD may serve as evidence contribution to 
      atherogenesis and myocardial ischemia.
FAU - Sinkiewicz, Wladyslaw
AU  - Sinkiewicz W
AD  - Department of Clinical Bases of Physiotherapy, Collegium Medicum Nicolaus 
      Copernicus University, Torun, Poland. wsinkiewicz@cm.umk.pl 
      <wsinkiewicz@cm.umk.pl>
FAU - Blazejewski, Jan
AU  - Blazejewski J
FAU - Bujak, Robert
AU  - Bujak R
FAU - Kubica, Jacek
AU  - Kubica J
FAU - Dudziak, Joanna
AU  - Dudziak J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Acute Coronary Syndrome/blood/immunology
MH  - Angina Pectoris/blood/immunology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/immunology
MH  - Myocardial Ischemia/*blood/*immunology
EDAT- 2008/07/25 09:00
MHDA- 2008/10/23 09:00
CRDT- 2008/07/25 09:00
PHST- 2008/07/25 09:00 [pubmed]
PHST- 2008/10/23 09:00 [medline]
PHST- 2008/07/25 09:00 [entrez]
PST - ppublish
SO  - Cardiol J. 2008;15(2):122-8.