PMID- 18651707
OWN - NLM
STAT- MEDLINE
DCOM- 20081216
LR  - 20151119
IS  - 1615-9861 (Electronic)
IS  - 1615-9853 (Linking)
VI  - 8
IP  - 16
DP  - 2008 Aug
TI  - Glycosaminoglycan-binding cytokines as tumor markers.
PG  - 3350-9
LID - 10.1002/pmic.200800042 [doi]
AB  - A significant proportion of cytokines bind to glycosaminoglycans such as heparin. 
      Glycosaminoglycans are involved in signaling, stabilization and/or storage of 
      these cytokines. Typical examples of glycosaminoglycan-binding cytokines are 
      basic fibroblast growth factor (bFGF), interleukin-8 (IL-8), monocyte 
      chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF), 
      VEGF-C, hepatocyte growth factor (HGF), granulocyte colony-stimulating factor 
      (G-CSF), midkine, and pleiotrophin. All are present in the tumor microenvironment 
      and promote tumor growth, tumor invasion and/or tumor angiogenesis. Serum or 
      plasma levels of glycosaminoglycan-binding cytokines are frequently elevated in 
      patients with various malignant tumors. High levels of these cytokines are 
      usually correlated with the occurrence of metastasis and a poor prognosis. The 
      mode of elevation of individual glycosaminoglycan-binding cytokines in patients 
      with malignant tumors is summarized here. Further studies, especially with 
      multiple cytokines, are expected to make assays clinically useful for both early 
      detection and prognostic prediction.
FAU - Muramatsu, Takashi
AU  - Muramatsu T
AD  - Department of Health Science, Faculty of Psychological and Physical Science, 
      Aichi Gakuin University, Nisshin, Aichi, Japan. tmurama@dpc.agu.ac.jp
FAU - Muramatsu, Hisako
AU  - Muramatsu H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Proteomics
JT  - Proteomics
JID - 101092707
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cytokines)
RN  - 0 (Glycosaminoglycans)
RN  - 0 (Interleukin-8)
RN  - 0 (Vascular Endothelial Growth Factor C)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Biomarkers, Tumor/*blood/metabolism
MH  - Cytokines/*blood/metabolism
MH  - Fibroblast Growth Factor 2/blood/metabolism
MH  - Glycosaminoglycans/*metabolism
MH  - Humans
MH  - Interleukin-8/blood/metabolism
MH  - Neoplasms/blood/diagnosis/pathology
MH  - Protein Binding
MH  - Vascular Endothelial Growth Factor C/blood/metabolism
RF  - 146
EDAT- 2008/07/25 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/07/25 09:00
PHST- 2008/07/25 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/07/25 09:00 [entrez]
AID - 10.1002/pmic.200800042 [doi]
PST - ppublish
SO  - Proteomics. 2008 Aug;8(16):3350-9. doi: 10.1002/pmic.200800042.