PMID- 18652308
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20080725
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 22
IP  - 9
DP  - 2008 May
TI  - [Study on relationship between intratumoral lymphangiogenesis of laryngeal 
      squamous cell carcinoma and lymphatic metastasis].
PG  - 385-8
AB  - OBJECTIVE: To elucidate the relationship between the intratumoral 
      lymphangiogenesis and lymphatic metastasis, and provide some theoretic evidence 
      for the judgement of lymph node metastasis and prognosis of laryngeal squamous 
      cell carcinoma (LSCC), also for the treatment. METHOD: Immunohistochemical 
      analysis was performed to 50 specimens of LSCC with lymphatic endothelial marker 
      (Lymphatic vessel endothelial hyaluronan receptor-1 LYVE-1), the vascular 
      endothelial marker CD34 and the pKi67 proliferation marker to record lymphatic 
      vessel density (LVD). Quantitation of lymphangiogenesis growth factor VEGF-C by 
      RT- PCR was performed to 30 specimens of LSCC. Finally the correlation between 
      LVD and tumor TNM grade, VEGF-C mRNA, grade of diffraction was analyzed with 
      statistics methods. RESULT: Newly proliferating lymphatic vessel were observed in 
      all LSCC. The median copy number of VEGF-c mRNA was 4-5-fold higher in LSCC than 
      in adjacent normal tissue. There was correlation between tumor VEGF-C mRNA copy 
      number and intratumoral LVD (n =30, P <0.05), there was no significant 
      association between LVD and sex, T stage and grade of diffraction (n =50, P 
      >0.05) but N stage (n = 50, P <0.05). CONCLUSION: Newly proliferating lymphatic 
      vessels existed in LSCC. There was correlation between high levels of LVD in LSCC 
      than in normal tissue. And the high level of VEGF-C may accelerate the lymphatic 
      metastasis by promoting the proliferation of intratumoral lymphatic.
FAU - Huangfu, Hui
AU  - Huangfu H
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430022, China. 
      huangfu83@yahoo.com.cn
FAU - Kong, Weijia
AU  - Kong W
FAU - Gong, Shusheng
AU  - Gong S
FAU - Wang, Binquan
AU  - Wang B
FAU - Zhang, Chunming
AU  - Zhang C
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (VEGFC protein, human)
RN  - 0 (Vascular Endothelial Growth Factor C)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/metabolism/*pathology
MH  - *Lymphangiogenesis
MH  - Lymphatic Metastasis
MH  - Lymphatic Vessels/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Vascular Endothelial Growth Factor C/metabolism
EDAT- 2008/07/26 09:00
MHDA- 2011/06/17 06:00
CRDT- 2008/07/26 09:00
PHST- 2008/07/26 09:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
PHST- 2008/07/26 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 May;22(9):385-8.