PMID- 18652358
OWN - NLM
STAT- MEDLINE
DCOM- 20090429
LR  - 20080725
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 33
IP  - 9
DP  - 2008 May
TI  - [Changes of proteomic spectra of total flavones of Hippophae rhamnoides on 
      myocardial protection].
PG  - 1060-3
AB  - OBJECTIVE: To study the mechanisms of the anti-myocardial ischemia of total 
      flavones of Hippophae rhamnoides (TFH) at the level of proteome. METHOD: Surface 
      enhanced laser desorption/ionization (SELDI) mass spectrometry with protein chip 
      IMAC3, SAX2 and NP20 was performed to compare the differentially expressed 
      protein in myocardial ischemia in the TFH-treated groups with the 0.9% sodium 
      chloride groups. Protein chips were examined in PBS II - C protein chip reader 
      (ciphergen ciosystem inc) and the protein profiling was analyzed by Proteinchip 
      Software 3. 0. 2. RESULT: The revealed six peaks had significant difference 
      between the TFH-treated groups and the control groups, one of which were 
      up-regulated in the TFH-treated groups, and the other were down-regulated. And in 
      these six distinct proteins, there were four proteins on the IMAC3 chips and one 
      protein on the SAX2 chips. CONCLUSION: The TFH could prevent the myocardium from 
      ischemia via regulating expression of different proteins.
FAU - Liu, Zheng-Ran
AU  - Liu ZR
AD  - Department of Cardiovascular Research, Baotou Medical college, Baotou 014010, 
      China. lzr13039570839@sina.com
FAU - Zhang, Qi
AU  - Zhang Q
FAU - Yang, Yu-Mei
AU  - Yang YM
FAU - Guan, Hui
AU  - Guan H
FAU - Liu, Feng-Ming
AU  - Liu FM
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Flavones)
SB  - IM
MH  - Animals
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Female
MH  - Flavones/chemistry/*pharmacology
MH  - Heart/*drug effects
MH  - Hippophae/*chemistry
MH  - Male
MH  - Myocardial Ischemia/prevention & control
MH  - Proteomics/*methods
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
EDAT- 2008/07/26 09:00
MHDA- 2009/04/30 09:00
CRDT- 2008/07/26 09:00
PHST- 2008/07/26 09:00 [pubmed]
PHST- 2009/04/30 09:00 [medline]
PHST- 2008/07/26 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2008 May;33(9):1060-3.