PMID- 18652591
OWN - NLM
STAT- MEDLINE
DCOM- 20091001
LR  - 20211020
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Print)
IS  - 1015-6305 (Linking)
VI  - 19
IP  - 3
DP  - 2009 Jul
TI  - Chordoid glioma: a case report and molecular characterization of five cases.
PG  - 439-48
LID - 10.1111/j.1750-3639.2008.00196.x [doi]
AB  - Chordoid gliomas are rare, slow-growing neoplasms of the anterior third 
      ventricle. We reported a case of chordoid glioma in a 41-year-old man with 
      obstructive hydrocephalus. Histologically, the tumor consisted of polygonal 
      epithelioid cells admixed with elongated cells in a myxoid stroma. A prominent 
      lymphoplasmacytic infiltrate was present. The tumor cells expressed glial 
      fibrillary acidic protein (GFAP), epithelial membrane antigen (EMA), vimentin, 
      CD31, CD34, epidermal growth factor receptor (EGFR) and S100 but were negative 
      for pankeratin and E-cadherin. The percentage of Ki67 positive cells was 
      approximately 3%. Weak p53 immunoreactivity was seen in less than 10% of the 
      cells. Array comparative genomic hybridization performed on this case, as well as 
      on four other archived cases, showed losses at several loci. Fluorescence in situ 
      hybridization (FISH) confirmed consistent genetic alterations at 9p21 and 11q13. 
      These are the fifth through ninth reported cases of chordoid gliomas with 
      molecular characterization suggesting a distinct genetic origin from other 
      gliomas.
FAU - Horbinski, Craig
AU  - Horbinski C
AD  - Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA 15213, USA. horbinskicm@upmc.edu
FAU - Dacic, Sanja
AU  - Dacic S
FAU - McLendon, Roger E
AU  - McLendon RE
FAU - Cieply, Kathy
AU  - Cieply K
FAU - Datto, Michael
AU  - Datto M
FAU - Brat, Daniel J
AU  - Brat DJ
FAU - Chu, Charleen T
AU  - Chu CT
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080723
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
SB  - IM
MH  - Adult
MH  - Cerebral Ventricle Neoplasms/*genetics/*pathology/surgery
MH  - Comparative Genomic Hybridization
MH  - Female
MH  - Glioma/*genetics/*pathology/surgery
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Microdissection
MH  - Middle Aged
MH  - Neurosurgical Procedures
MH  - Polymerase Chain Reaction
MH  - Third Ventricle/*pathology
MH  - Tomography, X-Ray Computed
PMC - PMC8094692
EDAT- 2008/07/26 09:00
MHDA- 2009/10/02 06:00
PMCR- 2008/07/24
CRDT- 2008/07/26 09:00
PHST- 2008/07/26 09:00 [pubmed]
PHST- 2009/10/02 06:00 [medline]
PHST- 2008/07/26 09:00 [entrez]
PHST- 2008/07/24 00:00 [pmc-release]
AID - BPA196 [pii]
AID - 10.1111/j.1750-3639.2008.00196.x [doi]
PST - ppublish
SO  - Brain Pathol. 2009 Jul;19(3):439-48. doi: 10.1111/j.1750-3639.2008.00196.x. Epub 
      2008 Jul 23.