PMID- 18652998
OWN - NLM
STAT- MEDLINE
DCOM- 20080902
LR  - 20220419
IS  - 1473-3099 (Print)
IS  - 1474-4457 (Electronic)
IS  - 1473-3099 (Linking)
VI  - 8
IP  - 8
DP  - 2008 Aug
TI  - Tuberculosis-associated immune reconstitution inflammatory syndrome: case 
      definitions for use in resource-limited settings.
PG  - 516-23
LID - 10.1016/S1473-3099(08)70184-1 [doi]
AB  - The immune reconstitution inflammatory syndrome (IRIS) has emerged as an 
      important early complication of antiretroviral therapy (ART) in resource-limited 
      settings, especially in patients with tuberculosis. However, there are no 
      consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, 
      previously proposed case definitions are not readily applicable in settings where 
      laboratory resources are limited. As a result, existing studies on 
      tuberculosis-associated IRIS have used a variety of non-standardised general case 
      definitions. To rectify this problem, around 100 researchers, including 
      microbiologists, immunologists, clinicians, epidemiologists, clinical trialists, 
      and public-health specialists from 16 countries met in Kampala, Uganda, in 
      November, 2006. At this meeting, consensus case definitions for paradoxical 
      tuberculosis-associated IRIS, ART-associated tuberculosis, and unmasking 
      tuberculosis-associated IRIS were derived, which can be used in high-income and 
      resource-limited settings. It is envisaged that these definitions could be used 
      by clinicians and researchers in a variety of settings to promote standardisation 
      and comparability of data.
FAU - Meintjes, Graeme
AU  - Meintjes G
AD  - Institute of Infectious Diseases and Molecular Medicine and Department of 
      Medicine, University of Cape Town, Cape Town, South Africa.
FAU - Lawn, Stephen D
AU  - Lawn SD
FAU - Scano, Fabio
AU  - Scano F
FAU - Maartens, Gary
AU  - Maartens G
FAU - French, Martyn A
AU  - French MA
FAU - Worodria, William
AU  - Worodria W
FAU - Elliott, Julian H
AU  - Elliott JH
FAU - Murdoch, David
AU  - Murdoch D
FAU - Wilkinson, Robert J
AU  - Wilkinson RJ
FAU - Seyler, Catherine
AU  - Seyler C
FAU - John, Laurence
AU  - John L
FAU - van der Loeff, Maarten Schim
AU  - van der Loeff MS
FAU - Reiss, Peter
AU  - Reiss P
FAU - Lynen, Lut
AU  - Lynen L
FAU - Janoff, Edward N
AU  - Janoff EN
FAU - Gilks, Charles
AU  - Gilks C
FAU - Colebunders, Robert
AU  - Colebunders R
CN  - International Network for the Study of HIV-associated IRIS
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 072070/WT_/Wellcome Trust/United Kingdom
GR  - MC_U117588499/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lancet Infect Dis
JT  - The Lancet. Infectious diseases
JID - 101130150
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/drug therapy/immunology/microbiology
MH  - Anti-HIV Agents/*therapeutic use
MH  - Antitubercular Agents/therapeutic use
MH  - HIV Infections/*complications/drug therapy/immunology
MH  - Health Resources
MH  - Humans
MH  - Immune Reconstitution Inflammatory 
      Syndrome/*diagnosis/immunology/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Poverty
MH  - Tuberculosis, Pulmonary/drug therapy/*immunology/*physiopathology
PMC - PMC2804035
MID - UKMS5154
OID - NLM: UKMS5154
EDAT- 2008/07/26 09:00
MHDA- 2008/09/03 09:00
PMCR- 2010/01/10
CRDT- 2008/07/26 09:00
PHST- 2008/07/26 09:00 [pubmed]
PHST- 2008/09/03 09:00 [medline]
PHST- 2008/07/26 09:00 [entrez]
PHST- 2010/01/10 00:00 [pmc-release]
AID - S1473-3099(08)70184-1 [pii]
AID - 10.1016/S1473-3099(08)70184-1 [doi]
PST - ppublish
SO  - Lancet Infect Dis. 2008 Aug;8(8):516-23. doi: 10.1016/S1473-3099(08)70184-1.