PMID- 18654637
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100610
LR  - 20220331
IS  - 1570-159X (Print)
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Linking)
VI  - 4
IP  - 4
DP  - 2006 Oct
TI  - Neurochemistry of the nucleus accumbens and its relevance to depression and 
      antidepressant action in rodents.
PG  - 277-91
AB  - There is accumulating evidence that the nucleus accumbens (NAc) plays an 
      important role in the pathophysiology of depression. Given that clinical 
      depression is marked by anhedonia (diminished interest or pleasure), dysfunction 
      of the brain reward pathway has been suggested as contributing to the 
      pathophysiology of depression.Since the NAc is the center of reward and learning, 
      it is hypothesized that anhedonia might be produced by hampering the function of 
      the NAc. Indeed, it has been reported that stress, drug exposure and drug 
      withdrawal, all of which produce a depressive-phenotype, alter various functions 
      within the NAc, leading to inhibited dopaminergic activity in the NAc.In this 
      review, we describe various factors as possible candidates within the NAc for the 
      initiation of depressive symptoms. First, we discuss the roles of several 
      neurotransmitters and neuropeptides in the functioning of the NAc, including 
      dopamine, glutamate, gamma-aminobutyric acid (GABA), acetylcholine, serotonin, 
      dynorphin, enkephaline, brain-derived neurotrophic factor (BDNF), cAMP response 
      element-binding protein (CREB), melanin-concentrating hormone (MCH) and cocaine- 
      and amphetamine-regulated transcript (CART). Second, based on previous studies, 
      we propose hypothetical relationships among these substances and the shell and 
      core subregions of the NAc.
FAU - Shirayama, Yukihiko
AU  - Shirayama Y
AD  - Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, 
      Japan. shirayama@rapid.ocn.ne.jp
FAU - Chaki, Shigeyuki
AU  - Chaki S
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
PMC - PMC2475798
OTO - NOTNLM
OT  - Depression
OT  - acetylcholine
OT  - cAMP response element-binding protein (CREB)
OT  - dopamine
OT  - dynorphin
OT  - glutamate
OT  - nucleus accumbens
OT  - gamma-aminobutyric acid (GABA)
EDAT- 2008/07/26 09:00
MHDA- 2008/07/26 09:01
PMCR- 2007/10/01
CRDT- 2008/07/26 09:00
PHST- 2005/06/30 00:00 [received]
PHST- 2005/09/06 00:00 [revised]
PHST- 2006/02/08 00:00 [accepted]
PHST- 2008/07/26 09:00 [pubmed]
PHST- 2008/07/26 09:01 [medline]
PHST- 2008/07/26 09:00 [entrez]
PHST- 2007/10/01 00:00 [pmc-release]
AID - CN-4-4-277 [pii]
AID - 10.2174/157015906778520773 [doi]
PST - ppublish
SO  - Curr Neuropharmacol. 2006 Oct;4(4):277-91. doi: 10.2174/157015906778520773.