PMID- 18655811
OWN - NLM
STAT- MEDLINE
DCOM- 20081202
LR  - 20211020
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 62
IP  - 2
DP  - 2008 Oct
TI  - Peripheral AMPA receptors contribute to muscle nociception and c-fos activation.
PG  - 97-104
LID - 10.1016/j.neures.2008.06.007 [doi]
AB  - In this study, involvement of peripheral AMPA receptors in mediating craniofacial 
      muscle pain was investigated. AMPA receptor subunits, GluR1 and GluR2, were 
      predominantly expressed in small to medium size neurons but more GluR2 positive 
      labeling were encountered in trigeminal ganglia (TG) of male Sprague Dawley rats. 
      A greater prevalence of GluR2 is reflected by the significantly higher percentage 
      of GluR2 than GluR1 positive masseter afferents. Nocifensive behavior and c-fos 
      immunoreactivity were assessed from the same animals that received intramuscular 
      mustard oil (MO) with or without NBQX, a potent AMPA/KA receptor antagonist. 
      Masseteric MO produced nocifensive hindpaw shaking responses that peaked in the 
      first 30s and gradually diminished over a few minutes. There was a significant 
      difference in both peak and overall MO-induced nocifensive responses between NBQX 
      and vehicle pre-treated rats. Subsequent Fos studies also showed that peripheral 
      NBQX pre-treatment effectively reduced the MO-induced neuronal activation in the 
      subnucleus caudalis of the trigeminal nerve (Vc). These combined results provide 
      compelling evidence that acute muscle nociception is mediated, in part, by 
      peripherally located AMPA/KA receptors, and that blockade of multiple peripheral 
      glutamate receptor subtypes may provide a more effective means of reducing 
      muscular pain and central neuronal activation.
FAU - Chun, Yang-Hyun
AU  - Chun YH
AD  - Kyung Hee University, School of Dentistry, Department of Oral Medicine, 1 Hoegi 
      Dong, Dongdaemun Gu, Seoul, Republic of Korea.
FAU - Frank, Dorie
AU  - Frank D
FAU - Lee, Jong-Seok
AU  - Lee JS
FAU - Zhang, Youping
AU  - Zhang Y
FAU - Auh, Q-Schick
AU  - Auh QS
FAU - Ro, Jin Y
AU  - Ro JY
LA  - eng
GR  - R01 DE016062/DE/NIDCR NIH HHS/United States
GR  - R01 DE016062-04/DE/NIDCR NIH HHS/United States
GR  - DE016062/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080706
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Plant Oils)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Quinoxalines)
RN  - 0 (Receptors, AMPA)
RN  - 118876-58-7 (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline)
RN  - TYY1MA9BSY (mustard oil)
SB  - IM
MH  - Animals
MH  - Enzyme Activation/*physiology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Facial Pain/chemically induced/*metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Masseter Muscle/drug effects/*innervation/metabolism
MH  - Mustard Plant/toxicity
MH  - Neurons, Afferent/drug effects/metabolism
MH  - Plant Oils/toxicity
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Quinoxalines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, AMPA/*metabolism
MH  - Trigeminal Nucleus, Spinal
PMC - PMC2636681
MID - NIHMS77153
EDAT- 2008/07/29 09:00
MHDA- 2008/12/17 09:00
PMCR- 2009/10/01
CRDT- 2008/07/29 09:00
PHST- 2008/05/06 00:00 [received]
PHST- 2008/06/04 00:00 [revised]
PHST- 2008/06/16 00:00 [accepted]
PHST- 2008/07/29 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/07/29 09:00 [entrez]
PHST- 2009/10/01 00:00 [pmc-release]
AID - S0168-0102(08)00184-3 [pii]
AID - 10.1016/j.neures.2008.06.007 [doi]
PST - ppublish
SO  - Neurosci Res. 2008 Oct;62(2):97-104. doi: 10.1016/j.neures.2008.06.007. Epub 2008 
      Jul 6.