PMID- 18656694
OWN - NLM
STAT- MEDLINE
DCOM- 20080815
LR  - 20080728
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 185
IP  - 1
DP  - 2008 Aug
TI  - RUNX1-MTG16 fusion gene in acute myeloblastic leukemia with t(16;21)(q24;q22): 
      case report and review of the literature.
PG  - 47-50
LID - 10.1016/j.cancergencyto.2008.04.011 [doi]
AB  - We report here a 73-year old female who was admitted for hematomas, dyspnea, and 
      fever. Hematological data showed pancytopenia with 9% blast cells positive for 
      CD13, CD33, CD34, HLAD2, and myeloperoxydase. A diagnosis of acute myeloid 
      leukemia (AML) type 2 (FAB classification) was made. Banding cytogenetic 
      techniques performed on bone marrow cells showed a 48,XX,+8,+9,del(9)(q22q33)x2 
      ,t(16;21)(q24;q22)[20]/46,XX[2] karyotype. Fluorescence in situ hybridization 
      (FISH) with BACs covering the RUNX1 (alias AML1) (band 21q22) and MTG16 (band 
      16q24) gene showed a fusion of both genes. The t(16;21)(q24;q22) has been 
      described in 16 AML cases, including ours. Eleven patients had received 
      chemotherapy for a previous cancer, most of them were been treated with 
      DNA-topoisomerase II inhibitors known to be associated with chromosomal 
      translocations involving the RUNX1 gene. The significant homology between MGT16 
      and MTG8 suggests that the RUNX1-MTG16 fusion gene induced by the 
      t(16;21)(q24;q22) is a variant of the RUNX1-MTG8 that shares similar activity.
FAU - De Braekeleer, Etienne
AU  - De Braekeleer E
AD  - Laboratoire d'Histologie, Embryologie et Cytogenetique, Faculte de Medecine et 
      des Sciences de la Sante, Universite de Bretagne Occidentale, F-29238 Brest, 
      Cedex 3, France.
FAU - Douet-Guilbert, Nathalie
AU  - Douet-Guilbert N
FAU - Le Bris, Marie-Josee
AU  - Le Bris MJ
FAU - Morel, Frederic
AU  - Morel F
FAU - Ferec, Claude
AU  - Ferec C
FAU - De Braekeleer, Marc
AU  - De Braekeleer M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (CBFA2T3 protein, human)
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Phosphoproteins)
RN  - 0 (RUNX1 protein, human)
RN  - 0 (Repressor Proteins)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Aged
MH  - Chromosome Deletion
MH  - Chromosomes, Artificial, Bacterial
MH  - *Chromosomes, Human, Pair 16
MH  - *Chromosomes, Human, Pair 21
MH  - Core Binding Factor Alpha 2 Subunit/*genetics
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/classification/diagnosis/*genetics
MH  - Oncogene Proteins, Fusion/genetics
MH  - Phosphoproteins/*genetics
MH  - Repressor Proteins/*genetics
MH  - *Translocation, Genetic
MH  - Tumor Suppressor Proteins/*genetics
RF  - 22
EDAT- 2008/07/29 09:00
MHDA- 2008/08/16 09:00
CRDT- 2008/07/29 09:00
PHST- 2008/01/30 00:00 [received]
PHST- 2008/04/05 00:00 [revised]
PHST- 2008/04/14 00:00 [accepted]
PHST- 2008/07/29 09:00 [pubmed]
PHST- 2008/08/16 09:00 [medline]
PHST- 2008/07/29 09:00 [entrez]
AID - S0165-4608(08)00265-3 [pii]
AID - 10.1016/j.cancergencyto.2008.04.011 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2008 Aug;185(1):47-50. doi: 
      10.1016/j.cancergencyto.2008.04.011.