PMID- 18656896 OWN - NLM STAT- MEDLINE DCOM- 20090319 LR - 20220409 IS - 0022-3956 (Print) IS - 0022-3956 (Linking) VI - 43 IP - 3 DP - 2009 Jan TI - Differential effects of ziprasidone and haloperidol on immobilization stress-induced mRNA BDNF expression in the hippocampus and neocortex of rats. PG - 274-81 LID - 10.1016/j.jpsychires.2008.05.010 [doi] AB - Recent in vivo and in vitro experiments have demonstrated that second-generation antipsychotic drugs (SGAs) might have neuroprotective effects. Ziprasidone is a SGA that is efficacious in the treatment of schizophrenia. In this study, we sought to analyze the effects of ziprasidone on the expression of the neuroprotective protein brain-derived neurotrophic factor (BDNF) in the rat hippocampus and neocortex, with or without immobilization stress. The effect of ziprasidone (2.5mg/kg) on the expression of BDNF mRNA was determined by in situ hybridization in tissue sections from the rat hippocampus and neocortex. Haloperidol (1.0mg/kg) was used for comparison. Haloperidol strongly decreased the expression of BDNF mRNA in both the hippocampal and cortical regions, with or without immobilization stress (p<0.01). In contrast, the administration of ziprasidone significantly attenuated the immobilization stress-induced decrease in BDNF mRNA expression in the rat hippocampus and neocortex (p<0.01). Ziprasidone exhibited differential effects on BDNF mRNA expression in the rat hippocampus and neocortex. These results suggest that ziprasidone might have a neuroprotective effect by recovering stress-induced decreases in BDNF mRNA expression. FAU - Park, Sung Woo AU - Park SW AD - Paik Institute for Clinical Research, Inje University, Busan, Republic of Korea. FAU - Lee, Chan Hong AU - Lee CH FAU - Lee, Jung Goo AU - Lee JG FAU - Lee, Sun Jung AU - Lee SJ FAU - Kim, Na Ri AU - Kim NR FAU - Choi, Sang Mi AU - Choi SM FAU - Kim, Young Hoon AU - Kim YH LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20080725 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 RN - 0 (Antipsychotic Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Piperazines) RN - 0 (RNA, Messenger) RN - 0 (Thiazoles) RN - 6UKA5VEJ6X (ziprasidone) RN - J6292F8L3D (Haloperidol) SB - IM MH - Animals MH - Antipsychotic Agents/administration & dosage/pharmacology MH - Brain-Derived Neurotrophic Factor/*genetics MH - Gene Expression/drug effects MH - Haloperidol/administration & dosage/*pharmacology MH - Hippocampus/*drug effects/metabolism MH - In Situ Hybridization/methods MH - Injections, Intraperitoneal MH - Male MH - Neocortex/*drug effects/metabolism MH - Piperazines/administration & dosage/*pharmacology MH - RNA, Messenger/genetics/metabolism MH - Rats MH - Rats, Sprague-Dawley MH - Restraint, Physical/adverse effects MH - Stress, Psychological/etiology/*physiopathology MH - Thiazoles/administration & dosage/*pharmacology EDAT- 2008/07/29 09:00 MHDA- 2009/03/20 09:00 CRDT- 2008/07/29 09:00 PHST- 2008/02/19 00:00 [received] PHST- 2008/05/06 00:00 [revised] PHST- 2008/05/26 00:00 [accepted] PHST- 2008/07/29 09:00 [pubmed] PHST- 2009/03/20 09:00 [medline] PHST- 2008/07/29 09:00 [entrez] AID - S0022-3956(08)00119-2 [pii] AID - 10.1016/j.jpsychires.2008.05.010 [doi] PST - ppublish SO - J Psychiatr Res. 2009 Jan;43(3):274-81. doi: 10.1016/j.jpsychires.2008.05.010. Epub 2008 Jul 25.