PMID- 18657242
OWN - NLM
STAT- MEDLINE
DCOM- 20080925
LR  - 20080728
IS  - 1399-5618 (Electronic)
IS  - 1398-5647 (Linking)
VI  - 10
IP  - 5
DP  - 2008 Jul
TI  - Association between brain-derived neurotrophic factor gene and a severe form of 
      bipolar disorder, but no interaction with the serotonin transporter gene.
PG  - 580-7
LID - 10.1111/j.1399-5618.2008.00603.x [doi]
AB  - BACKGROUND: Recent data suggest that brain-derived neurotrophic factor (BDNF) and 
      the serotonergic system are involved and interact in major depressive disorder 
      and suicidal behavior (SB). Several family and population-based studies have 
      reported associations between the BDNF gene and serotonin-related genes, 
      specifically the serotonin transporter (5HTT) gene, with bipolar disorder (BD) 
      and SB. However, despite the fact that gene-by-gene interaction between BDNF and 
      5HTT has been demonstrated in monoamine deficiencies in animals, this kind of 
      interaction has never been tested in humans. Our hypothesis is that some BDNF and 
      5HTT polymorphisms might confer increased risk for BD and SB and that both genes 
      may interact with each other. METHODS: To test this hypothesis, we genotyped the 
      most common BDNF polymorphisms, G196A (Val66Met), A-633T and BDNF-LCPR, as well 
      as 5HTT (5HTT-LPR), in 447 BD patients and 370 controls. RESULTS: We replicated 
      the association previously reported between BDNF G196A (Val66Met) polymorphism 
      and BD. We also observed a correlation between the number of G196 alleles and 
      short alleles of 5HTT-LPR and the severity of SB in BD. However, we found no 
      significant interaction between these two markers. CONCLUSIONS: These results 
      suggest that BDNF G196A as well as 5HTT-LPR polymorphisms confer risk for SB in 
      BD, but we did not observe any evidence for an interaction between them.
FAU - Vincze, Ilona
AU  - Vincze I
AD  - Department of Psychiatry, University Hospital of Geneva, Geneva, Switzerland.
FAU - Perroud, Nader
AU  - Perroud N
FAU - Buresi, Catherine
AU  - Buresi C
FAU - Baud, Patrick
AU  - Baud P
FAU - Bellivier, Frank
AU  - Bellivier F
FAU - Etain, Bruno
AU  - Etain B
FAU - Fournier, Claire
AU  - Fournier C
FAU - Karege, Felicien
AU  - Karege F
FAU - Matthey, Marie-Louise
AU  - Matthey ML
FAU - Preisig, Martin
AU  - Preisig M
FAU - Leboyer, Marion
AU  - Leboyer M
FAU - Malafosse, Alain
AU  - Malafosse A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Bipolar Disorder/diagnosis/*genetics/psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Disease Susceptibility
MH  - Epistasis, Genetic
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Suicide, Attempted/*psychology
EDAT- 2008/07/29 09:00
MHDA- 2008/09/26 09:00
CRDT- 2008/07/29 09:00
PHST- 2008/07/29 09:00 [pubmed]
PHST- 2008/09/26 09:00 [medline]
PHST- 2008/07/29 09:00 [entrez]
AID - BDI603 [pii]
AID - 10.1111/j.1399-5618.2008.00603.x [doi]
PST - ppublish
SO  - Bipolar Disord. 2008 Jul;10(5):580-7. doi: 10.1111/j.1399-5618.2008.00603.x.