PMID- 1865728
OWN - NLM
STAT- MEDLINE
DCOM- 19910912
LR  - 20041117
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 101
IP  - 8
DP  - 1991 Aug
TI  - Allergic fungal sinusitis: problems in diagnosis and treatment.
PG  - 815-20
AB  - Although first described in 1983, allergic Aspergillus sinusitis (AAS) has yet to 
      gain wide recognition among otolaryngologists and pathologists. We have treated 
      three patients with a history of asthma, nasal polyposis, and recurrent 
      pansinusitis who fit the description of allergic Aspergillus sinusitis. 
      Histopathologically, mucinous material with abundant eosinophils and 
      Charcot-Leyden crystals ("allergic mucin") is interspersed with fungal hyphae. 
      Immunologic characteristics include serum total immunoglobulin E (IgE) elevation, 
      increased RAST classes, and cutaneous reactivity to molds. A retrospective 
      analysis of the histopathology of 82 patients with chronic sinusitis was also 
      undertaken. Eleven additional patients with classic allergic mucin were 
      identified, but were found to be without evidence of fungal elements. The 
      clinical features of all 14 patients are reviewed revealing the spectrum of 
      disease. The difficulties of diagnosis and a therapeutic protocol which includes 
      wide local debridement and postoperative use of systemic steroids are discussed.
FAU - Allphin, A L
AU  - Allphin AL
AD  - Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve 
      University School of Medicine, Cleveland, Ohio.
FAU - Strauss, M
AU  - Strauss M
FAU - Abdul-Karim, F W
AU  - Abdul-Karim FW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aspergillus/isolation & purification
MH  - Child
MH  - Chronic Disease
MH  - Humans
MH  - Hypersensitivity/diagnosis/*microbiology/therapy
MH  - Middle Aged
MH  - Mitosporic Fungi/isolation & purification
MH  - Mucus/microbiology
MH  - Mycoses/diagnosis/*microbiology/therapy
MH  - Retrospective Studies
MH  - Sinusitis/diagnosis/*microbiology/therapy
MH  - Tomography, X-Ray Computed
EDAT- 1991/08/01 00:00
MHDA- 1991/08/01 00:01
CRDT- 1991/08/01 00:00
PHST- 1991/08/01 00:00 [pubmed]
PHST- 1991/08/01 00:01 [medline]
PHST- 1991/08/01 00:00 [entrez]
AID - 10.1288/00005537-199108000-00003 [doi]
PST - ppublish
SO  - Laryngoscope. 1991 Aug;101(8):815-20. doi: 10.1288/00005537-199108000-00003.