PMID- 18657424
OWN - NLM
STAT- MEDLINE
DCOM- 20081023
LR  - 20220318
IS  - 0960-8966 (Print)
IS  - 0960-8966 (Linking)
VI  - 18
IP  - 8
DP  - 2008 Aug
TI  - Two cases of thymoma-associated myasthenia gravis without antibodies to the 
      acetylcholine receptor.
PG  - 678-80
LID - 10.1016/j.nmd.2008.06.368 [doi]
AB  - Thymoma-associated myasthenia gravis is considered a more severe disease compared 
      with non-thymomatous myasthenia gravis and is generally associated with 
      antibodies to the acetylcholine receptor (AChR-Ab). Even though a single case of 
      thymoma-associated myasthenia gravis with anti-muscle specific kinase (MuSK) 
      antibodies has been reported, to our knowledge, seronegative thymoma-associated 
      myasthenia gravis has not been described. We report on two cases of this disease 
      without antibodies to AChR or MuSK as a further evidence of the variability of 
      myasthenia gravis in terms of antibody profile and thymic pathological findings.
FAU - Maggi, Lorenzo
AU  - Maggi L
AD  - Immunology and Muscular Pathology Unit, Neurological Institute Foundation Carlo 
      Besta, Via Celoria 11, 20133 Milano, Italy. lorenzo.maggi@istituto-besta.it
FAU - Andreetta, Francesca
AU  - Andreetta F
FAU - Antozzi, Carlo
AU  - Antozzi C
FAU - Confalonieri, Paolo
AU  - Confalonieri P
FAU - Cornelio, Ferdinando
AU  - Cornelio F
FAU - Scaioli, Vidmer
AU  - Scaioli V
FAU - Mantegazza, Renato
AU  - Mantegazza R
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080725
PL  - England
TA  - Neuromuscul Disord
JT  - Neuromuscular disorders : NMD
JID - 9111470
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adult
MH  - Autoantibodies/*analysis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Myasthenia Gravis/immunology/*metabolism
MH  - Protein-Tyrosine Kinases/genetics
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - Receptors, Cholinergic/*immunology/*metabolism
MH  - Thymoma/*complications/immunology/pathology
MH  - Thymus Neoplasms/*complications/immunology/pathology
MH  - Tomography, X-Ray Computed
EDAT- 2008/07/29 09:00
MHDA- 2008/10/24 09:00
CRDT- 2008/07/29 09:00
PHST- 2008/01/29 00:00 [received]
PHST- 2008/06/16 00:00 [revised]
PHST- 2008/06/19 00:00 [accepted]
PHST- 2008/07/29 09:00 [pubmed]
PHST- 2008/10/24 09:00 [medline]
PHST- 2008/07/29 09:00 [entrez]
AID - S0960-8966(08)00533-6 [pii]
AID - 10.1016/j.nmd.2008.06.368 [doi]
PST - ppublish
SO  - Neuromuscul Disord. 2008 Aug;18(8):678-80. doi: 10.1016/j.nmd.2008.06.368. Epub 
      2008 Jul 25.