PMID- 18657572
OWN - NLM
STAT- MEDLINE
DCOM- 20081125
LR  - 20080825
IS  - 0145-305X (Print)
IS  - 0145-305X (Linking)
VI  - 32
IP  - 12
DP  - 2008
TI  - Differential expression of two interferon-gamma genes in common carp (Cyprinus 
      carpio L.).
PG  - 1467-81
LID - 10.1016/j.dci.2008.06.012 [doi]
AB  - Two interferon gamma (IFN-gamma) genes are expressed in immune cells of teleost 
      fish and are potentially implicated in B- and T-lymphocyte responses. IFN-gamma-2 
      shows structural and functional characteristics to other vertebrate IFN-gamma 
      genes and is associated with T-lymphocyte function. Expression profiling shows 
      IFN-gamma-2 upregulation in T-lymphocytes after phytohemagglutinin (PHA) 
      stimulation in vitro. Unexpectedly, we found IFN-gamma-1, which is structurally 
      different from IFN-gamma-2, to be expressed in lipopolysacharide (LPS)-stimulated 
      IgM+ (B- lymphocyte enriched) fractions. Expression of T-box transcription factor 
      T-bet, but not of GATA-binding protein 3 (GATA3), correlated with expression of 
      both IFN-gamma genes. In-vivo parasite infection, but as predicted not 
      zymosan-induced inflammation, resulted in concomitant upregulation of T-bet and 
      IFN-gamma-2. This corroborates a genuine T-lymphocyte associated role for 
      IFN-gamma-2.
FAU - Stolte, Ellen H
AU  - Stolte EH
AD  - Cell Biology and Immunology Group, Wageningen University, Marijkeweg 40, 6709 PG 
      Wageningen, The Netherlands.
FAU - Savelkoul, Huub F J
AU  - Savelkoul HF
FAU - Wiegertjes, Geert
AU  - Wiegertjes G
FAU - Flik, Gert
AU  - Flik G
FAU - Lidy Verburg-van Kemenade, B M
AU  - Lidy Verburg-van Kemenade BM
LA  - eng
SI  - GENBANK/AM168523
SI  - GENBANK/AM261214
PT  - Comparative Study
PT  - Journal Article
DEP - 20080725
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Protein Isoforms)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Carps/*genetics/*immunology
MH  - Cattle
MH  - Cells, Cultured
MH  - Dogs
MH  - Gene Expression Regulation/*physiology
MH  - Humans
MH  - Interferon-gamma/*biosynthesis/*genetics/isolation & purification
MH  - Mice
MH  - Molecular Sequence Data
MH  - Protein Isoforms/biosynthesis/genetics/isolation & purification
MH  - Rabbits
MH  - Rats
MH  - Sequence Alignment
EDAT- 2008/07/29 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/07/29 09:00
PHST- 2008/04/09 00:00 [received]
PHST- 2008/06/05 00:00 [revised]
PHST- 2008/06/19 00:00 [accepted]
PHST- 2008/07/29 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/07/29 09:00 [entrez]
AID - S0145-305X(08)00148-1 [pii]
AID - 10.1016/j.dci.2008.06.012 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2008;32(12):1467-81. doi: 10.1016/j.dci.2008.06.012. Epub 2008 
      Jul 25.