PMID- 18660566
OWN - NLM
STAT- MEDLINE
DCOM- 20080925
LR  - 20161124
IS  - 0021-2571 (Print)
IS  - 0021-2571 (Linking)
VI  - 44
IP  - 2
DP  - 2008
TI  - Clozapine or Haloperidol in rats prenatally exposed to methylazoxymethanol, a 
      compound inducing entorhinal-hippocampal deficits, alter brain and blood 
      neurotrophins' concentrations.
PG  - 167-77
AB  - Rats exposed during prenatal life to methylazoxymethanol (MAM) display in 
      postnatal age structural and behavioral deficits resembling those observed in 
      schizophrenic patients. These deficits are associated with significant changes in 
      brain nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), 
      particularly in the hippocampus and entorhinal cortex. In the present study, we 
      used the MAM model to investigate in young rats the effect of antipsychotics, 
      Clozapine and Haloperidol, on brain and blood NGF and BDNF presence. Young 
      animals were used because administration of antipsychotics during adolescence is 
      a common feature of intervention. The results showed that administration of 
      Clozapine and Haloperidol causes significant changes in the concentration of NGF 
      and BDNF in the brain and bloodstream of MAM-treated rats. These findings 
      indicate that these drugs may affect the synthesis and release of neurotrophins 
      in the central nervous system and in the blood circulation. In addition, the MAM 
      model can be a useful tool to investigate the biochemical and molecular 
      mechanisms regarding the effects of antipsychotics.
FAU - Fiore, Marco
AU  - Fiore M
AD  - Istituto di Neurobiologia e Medicina Molecolare, Sezione NGF, Consiglio Nazionale 
      delle Ricerche, Rome, Italy.
FAU - Di Fausto, Veronica
AU  - Di Fausto V
FAU - Iannitelli, Angela
AU  - Iannitelli A
FAU - Aloe, Luigi
AU  - Aloe L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
RN  - 0 (Alkylating Agents)
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Nerve Growth Factors)
RN  - 592-62-1 (Methylazoxymethanol Acetate)
RN  - J60AR2IKIC (Clozapine)
RN  - J6292F8L3D (Haloperidol)
RN  - JGG19N3YDQ (methylazoxymethanol)
SB  - IM
MH  - *Alkylating Agents
MH  - Animals
MH  - Antipsychotic Agents/*pharmacology
MH  - Body Weight/drug effects
MH  - Brain Chemistry/*drug effects
MH  - Clozapine/*pharmacology
MH  - Entorhinal Cortex/abnormalities/*pathology
MH  - Female
MH  - Granulocytes/drug effects/metabolism
MH  - Haloperidol/*pharmacology
MH  - Hippocampus/abnormalities/*pathology
MH  - Methylazoxymethanol Acetate/*analogs & derivatives
MH  - Nerve Growth Factors/blood/*metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2008/07/29 09:00
MHDA- 2008/09/26 09:00
CRDT- 2008/07/29 09:00
PHST- 2008/07/29 09:00 [pubmed]
PHST- 2008/09/26 09:00 [medline]
PHST- 2008/07/29 09:00 [entrez]
PST - ppublish
SO  - Ann Ist Super Sanita. 2008;44(2):167-77.