PMID- 18662305
OWN - NLM
STAT- MEDLINE
DCOM- 20081031
LR  - 20080929
IS  - 1742-464X (Print)
IS  - 1742-464X (Linking)
VI  - 275
IP  - 18
DP  - 2008 Sep
TI  - Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients.
PG  - 4448-55
LID - 10.1111/j.1742-4658.2008.06580.x [doi]
AB  - Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that 
      primarily affects the small joints of the hands and feet. The inflammatory 
      process is characterized by infiltration of inflammatory cells into the joints, 
      leading to proliferation of synoviocytes and destruction of cartilage and bone. 
      In RA synovial tissue, the infiltrating cells such as macrophages, T cells, B 
      cells and dendritic cells play important role in the pathogenesis of RA. 
      Migration of leukocytes into the synovium is a regulated multi-step process, 
      involving interactions between leukocytes and endothelial cells, cellular 
      adhesion molecules, as well as chemokines and chemokine receptors. Chemokines are 
      small, chemoattractant cytokines which play key roles in the accumulation of 
      inflammatory cells at the site of inflammation. It is known that synovial tissue 
      and synovial fluid from RA patients contain increased concentrations of several 
      chemokines, such as monocyte chemoattractant protein-4 (MCP-4)/CCL13, pulmonary 
      and activation-regulated chemokine (PARC)/CCL18, monokine induced by 
      interferon-gamma (Mig)/CXCL9, stromal cell-derived factor 1 (SDF-1)/CXCL12, 
      monocyte chemotactic protein 1 (MCP-1)/CCL2, macrophage inflammatory protein 
      1alpha (MIP-1alpha)/CCL3, and Fractalkine/CXC3CL1. Therefore, chemokines and 
      chemokine-receptors are considered to be important molecules in RA pathology.
FAU - Iwamoto, Takuji
AU  - Iwamoto T
AD  - Institute of Rheumatology, Tokyo Women's Medical University, Japan.
FAU - Okamoto, Hiroshi
AU  - Okamoto H
FAU - Toyama, Yoshiaki
AU  - Toyama Y
FAU - Momohara, Shigeki
AU  - Momohara S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080724
PL  - England
TA  - FEBS J
JT  - The FEBS journal
JID - 101229646
RN  - 0 (Chemokines)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Arthritis, Rheumatoid/*immunology
MH  - Chemokines/genetics/*metabolism/physiology
MH  - Humans
MH  - Receptors, Chemokine/metabolism
MH  - Synovial Membrane/*immunology
RF  - 63
EDAT- 2008/07/30 09:00
MHDA- 2008/11/01 09:00
CRDT- 2008/07/30 09:00
PHST- 2008/07/30 09:00 [pubmed]
PHST- 2008/11/01 09:00 [medline]
PHST- 2008/07/30 09:00 [entrez]
AID - EJB6580 [pii]
AID - 10.1111/j.1742-4658.2008.06580.x [doi]
PST - ppublish
SO  - FEBS J. 2008 Sep;275(18):4448-55. doi: 10.1111/j.1742-4658.2008.06580.x. Epub 
      2008 Jul 24.