PMID- 18662374
OWN - NLM
STAT- MEDLINE
DCOM- 20081031
LR  - 20231213
IS  - 1756-9966 (Electronic)
IS  - 0392-9078 (Print)
IS  - 0392-9078 (Linking)
VI  - 27
IP  - 1
DP  - 2008 Jul 28
TI  - Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a 
      case-control study.
PG  - 24
LID - 10.1186/1756-9966-27-24 [doi]
AB  - BACKGROUND: DNA-methyltransferase-3B (DNMT3B), which plays a role in DNA 
      methylation, is usually aberrant expression involved in carcinogenesis. 
      Polymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methylation 
      in several cancers, thereby modulating the susceptibility to cancer. METHODS: 
      DNMT3B -579G>T genotypes and -149C>T were determined by PCR-RFLP and sequencing 
      in 137 colorectal cancer patients and 308 controls matched for age and sex, who 
      did not receive radiotherapy or chemotherapy for newly diagnosed and 
      histopathologically confirmed colorectal cancer. The association between two SNPs 
      of the DNMT3B promoter and the risk of the development of colorectal cancer was 
      analyzed in a population of Chinese. RESULTS: The allele frequency of -149C >T 
      among patients and controls was 0.73% versus 0.65%, respectively. The allele 
      frequency of -597G>T for patients and controls was 6.57% versus 11.53%, 
      respectively. Individuals with at least one -149C>T allele were no at a 
      significantly increase risk of colorectal cancer compared with those having a 
      -149TT genotype. However, Individuals with at least one 579G>T allele were 
      decreased risk of colorectal cancer compared with those having a -579TT genotype. 
      CONCLUSION: The relative distribution of -149C>T DNMT3B SNPs among a Chinese 
      population can not be used as a stratification marker to predict an individual's 
      susceptibility to colorectal cancer. However, the DNMT3B -579G>T polymorphism may 
      contribute to the genetic susceptibility to colorectal cancer.
FAU - Fan, Hong
AU  - Fan H
AD  - Key Laboratory of Developmental genes and Human diseases, Ministry of Education, 
      Southeast University, 210009, Nanjing, PR China. fanh@seu.edu.cn.
FAU - Zhang, Feng
AU  - Zhang F
FAU - Hu, Jiabo
AU  - Hu J
FAU - Liu, Dongsheng
AU  - Liu D
FAU - Zhao, Zhujiang
AU  - Zhao Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080728
PL  - England
TA  - J Exp Clin Cancer Res
JT  - Journal of experimental & clinical cancer research : CR
JID - 8308647
RN  - EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases)
SB  - IM
MH  - Aged
MH  - Asian People/genetics
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Colorectal Neoplasms/*genetics/metabolism
MH  - DNA (Cytosine-5-)-Methyltransferases/*genetics
MH  - DNA Methylation
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Risk Factors
MH  - DNA Methyltransferase 3B
PMC - PMC2515831
EDAT- 2008/07/30 09:00
MHDA- 2008/11/01 09:00
PMCR- 2008/07/28
CRDT- 2008/07/30 09:00
PHST- 2008/06/03 00:00 [received]
PHST- 2008/07/28 00:00 [accepted]
PHST- 2008/07/30 09:00 [pubmed]
PHST- 2008/11/01 09:00 [medline]
PHST- 2008/07/30 09:00 [entrez]
PHST- 2008/07/28 00:00 [pmc-release]
AID - 1756-9966-27-24 [pii]
AID - 10.1186/1756-9966-27-24 [doi]
PST - epublish
SO  - J Exp Clin Cancer Res. 2008 Jul 28;27(1):24. doi: 10.1186/1756-9966-27-24.