PMID- 18662831
OWN - NLM
STAT- MEDLINE
DCOM- 20081106
LR  - 20080905
IS  - 1532-2742 (Electronic)
IS  - 0163-4453 (Linking)
VI  - 57
IP  - 3
DP  - 2008 Sep
TI  - Elevated serum cytokine levels are associated with human herpesvirus 6 
      reactivation in hematopoietic stem cell transplantation recipients.
PG  - 241-8
LID - 10.1016/j.jinf.2008.06.014 [doi]
AB  - Although it has been demonstrated that human herpesvirus 6 (HHV-6) reactivation 
      generally occurs approximately 2-3 weeks after transplantation in the 
      hematopoietic stem cell transplantation (HSCT) recipients, the mechanism of viral 
      reactivation remains unclear. To explore the relationship between HHV-6 
      reactivation and plasma cytokine levels, 24 HSCT recipients underwent 
      measurements of plasma proinflammatory cytokine levels (IL-6, TNF-alpha, IL-1 
      beta, and IFN-gamma), viral isolation, and serological assays. Of these patients, 
      14 developed an HHV-6 reactivation, and 9 developed HHV-6 viremia approximately 
      2-3 weeks after transplantation. IL-6 levels were significantly higher in the 
      recipients with an HHV-6 reactivation than in the subjects without an HHV-6 
      reactivation at 1 week, 2 weeks, and 4 weeks after transplantation. In addition, 
      the level of TNF-alpha was significantly higher in recipients with an HHV-6 
      reactivation than in those without an HHV-6 reactivation at 2 weeks 
      post-transplantation. Low levels of IL-1 beta and IFN-gamma were detected in a 
      small number of the plasma samples, although there were no significant 
      differences between the two groups in the levels of these cytokines. These 
      results imply that proinflammatory cytokines, in particular IL-6 and TNF-alpha, 
      play a role in the pathogenesis of HHV-6 reactivation after HSCT.
FAU - Fujita, Ayano
AU  - Fujita A
AD  - Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, 
      Aichi 4701192, Japan.
FAU - Ihira, Masaru
AU  - Ihira M
FAU - Suzuki, Ryota
AU  - Suzuki R
FAU - Enomoto, Yoshihiko
AU  - Enomoto Y
FAU - Sugiyama, Hiroko
AU  - Sugiyama H
FAU - Sugata, Ken
AU  - Sugata K
FAU - Suga, Sadao
AU  - Suga S
FAU - Asano, Yoshizo
AU  - Asano Y
FAU - Yagasaki, Hiroshi
AU  - Yagasaki H
FAU - Kojima, Seiji
AU  - Kojima S
FAU - Matsumoto, Kimikazu
AU  - Matsumoto K
FAU - Kato, Koji
AU  - Kato K
FAU - Yoshikawa, Tetsushi
AU  - Yoshikawa T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080726
PL  - England
TA  - J Infect
JT  - The Journal of infection
JID - 7908424
RN  - 0 (Cytokines)
SB  - IM
MH  - Adolescent
MH  - Child, Preschool
MH  - Cytokines/*blood
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Herpesvirus 6, Human/*immunology/isolation & purification
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Roseolovirus Infections/*immunology
MH  - Viremia
MH  - Virus Activation/*immunology
EDAT- 2008/07/30 09:00
MHDA- 2008/11/07 09:00
CRDT- 2008/07/30 09:00
PHST- 2007/12/20 00:00 [received]
PHST- 2008/04/24 00:00 [revised]
PHST- 2008/06/16 00:00 [accepted]
PHST- 2008/07/30 09:00 [pubmed]
PHST- 2008/11/07 09:00 [medline]
PHST- 2008/07/30 09:00 [entrez]
AID - S0163-4453(08)00219-3 [pii]
AID - 10.1016/j.jinf.2008.06.014 [doi]
PST - ppublish
SO  - J Infect. 2008 Sep;57(3):241-8. doi: 10.1016/j.jinf.2008.06.014. Epub 2008 Jul 
      26.