PMID- 18664129
OWN - NLM
STAT- MEDLINE
DCOM- 20080903
LR  - 20080730
IS  - 0041-3771 (Print)
IS  - 0041-3771 (Linking)
VI  - 50
IP  - 3
DP  - 2008
TI  - [Reorganization of actin cytoskeleton in 3T3-SV40 cells and their sensitivity to 
      lysis by natural killer cells].
PG  - 261-7
AB  - The present work was aimed to examine whether the actin reorganization of 
      3T3-SV40 cells influences their sensitivity to natural killer (NK) cells 
      activity. The effects of N-acetylcystein (NAC) and latrunculin B, actin 
      depolimerizator, on both cellular parameters were studied. Experiments with NAC 
      demonstrated that 3T3-SV40 sensitivity to NK cells activity remained unchanged 
      under the disordered microfilaments but decreased upon the appearance of 
      structured stress-fibres. The data on latrunculin B action resulted in the 
      opposite conclusion: the more microfilaments disorganization in the presence of 
      latrunculin B the lesser 3T3-SV40 sensitivity to lysis by NK cells. These facts 
      suggest that relations between microfilament integrity in 3T3-SV40 cells and 
      their sensitivity to NK cells are rather independent. The latter confirms our 
      previous conclusion (Gamaley et al., 2006). Decrease in 3T3-SV40 sensitivity to 
      NK cells activity accompanied by actin reorganization resulted from both 
      latrunculin B and NAC action suggests changes in cellular surface, which 
      ultimately lead to inactivation (or loss) of the molecules being activating 
      signals to NK cells.
FAU - Filatova, N A
AU  - Filatova NA
FAU - Kirpichnikova, K M
AU  - Kirpichnikova KM
FAU - Gamalei, I A
AU  - Gamalei IA
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Russia (Federation)
TA  - Tsitologiia
JT  - Tsitologiia
JID - 0417363
RN  - 0 (Actins)
SB  - IM
MH  - 3T3 Cells
MH  - Actins/*physiology
MH  - Animals
MH  - Cell Line, Transformed/*immunology/*metabolism
MH  - Cytotoxicity, Immunologic
MH  - Killer Cells, Natural/*immunology
MH  - Mice
MH  - Simian virus 40
EDAT- 2008/07/31 09:00
MHDA- 2008/09/04 09:00
CRDT- 2008/07/31 09:00
PHST- 2008/07/31 09:00 [pubmed]
PHST- 2008/09/04 09:00 [medline]
PHST- 2008/07/31 09:00 [entrez]
PST - ppublish
SO  - Tsitologiia. 2008;50(3):261-7.