PMID- 18664999
OWN - NLM
STAT- MEDLINE
DCOM- 20090115
LR  - 20220409
IS  - 1527-5418 (Electronic)
IS  - 0890-8567 (Linking)
VI  - 47
IP  - 9
DP  - 2008 Sep
TI  - Brain-derived neurotrophic factor gene expression in pediatric bipolar disorder: 
      effects of treatment and clinical response.
PG  - 1077-85
LID - 10.1097/CHI.0b013e31817eecd9 [doi]
AB  - OBJECTIVE: Pediatric bipolar disorder (PBD) is a major public health concern; 
      however, little is known about the cellular and genetic factors that are involved 
      in the pathophysiology of this illness. The observed structural abnormality in 
      the brains of patients with mood disorders has been related to abnormal 
      brain-derived neurotrophic factor (BDNF) function, suggesting an important role 
      for BDNF in these disorders. METHOD: We determined the gene expression of BDNF in 
      lymphocytes obtained from 26 PBD subjects during a drug-free baseline period and 
      during the eighth week of treatment (n = 19) and from 21 medication-free normal 
      control subjects. We also determined the protein levels of BDNF in platelets of 
      patients with PBD and normal control subjects. Subjects were diagnosed according 
      to DSM-IV diagnostic criteria using the Washington University at St. Louis 
      Schedule for Affective Disorders and Schizophrenia. RESULTS: The mRNA levels of 
      BDNF in lymphocytes of PBD subjects were significantly decreased compared with 
      those of normal control subjects and were significantly higher in 19 subjects 
      after 8 weeks of treatment than the pretreatment drug-free baseline levels and 
      similar to those of normal controls. Similarly, protein levels of BDNF were 
      decreased in platelets of patients with PBD. CONCLUSIONS: These studies suggest 
      that BDNF levels may be a potential biomarker for PBD. BDNF levels may also serve 
      as a potential treatment predictor and prognostic indicator in PBD.
FAU - Pandey, Ghanshyam N
AU  - Pandey GN
AD  - Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, 
      USA. Gnpandey@psych.uic.edu
FAU - Rizavi, Hooriyah S
AU  - Rizavi HS
FAU - Dwivedi, Yogesh
AU  - Dwivedi Y
FAU - Pavuluri, Mani N
AU  - Pavuluri MN
LA  - eng
GR  - R01-MH-56528/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Am Acad Child Adolesc Psychiatry
JT  - Journal of the American Academy of Child and Adolescent Psychiatry
JID - 8704565
RN  - 0 (Anticonvulsants)
RN  - 0 (Antimanic Agents)
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adolescent
MH  - Anticonvulsants/therapeutic use
MH  - Antimanic Agents/therapeutic use
MH  - Antipsychotic Agents/therapeutic use
MH  - Bipolar Disorder/diagnosis/drug therapy/*genetics
MH  - Blood Platelets/metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Lymphocytes/metabolism
MH  - Male
MH  - Prognosis
MH  - Psychiatric Status Rating Scales
MH  - RNA, Messenger/blood
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2008/07/31 09:00
MHDA- 2009/01/16 09:00
CRDT- 2008/07/31 09:00
PHST- 2008/07/31 09:00 [pubmed]
PHST- 2009/01/16 09:00 [medline]
PHST- 2008/07/31 09:00 [entrez]
AID - S0890-8567(08)60084-2 [pii]
AID - 10.1097/CHI.0b013e31817eecd9 [doi]
PST - ppublish
SO  - J Am Acad Child Adolesc Psychiatry. 2008 Sep;47(9):1077-85. doi: 
      10.1097/CHI.0b013e31817eecd9.