PMID- 18665759
OWN - NLM
STAT- MEDLINE
DCOM- 20090916
LR  - 20090202
IS  - 1937-3376 (Electronic)
IS  - 1937-3368 (Linking)
VI  - 14
IP  - 3
DP  - 2008 Sep
TI  - Current approaches and challenges in making a bio-tooth.
PG  - 307-19
LID - 10.1089/ten.teb.2008.0165 [doi]
AB  - Tooth loss adversely affects not only mouth functions but also the esthetics of 
      one's face. To repair these defects, current treatment methods mainly depend on 
      nonbiological materials or artificial implants that also can, sometimes, reduce 
      the quality of life because of their limited physiological function, or elicit an 
      immunological rejection. Theoretically, a biological tooth (bio-tooth) that is 
      made from the patient's own cells and grows in its intended location should be 
      the best choice for treating tooth loss, although such bioengineered teeth have 
      been nothing more than a dream for many centuries. Recently, significant advances 
      in the fields of tissue engineering, stem cell biology, developmental biology, 
      molecular genetics, and bionics have brought us close to the realization of a 
      bio-tooth. However, issues involving in the reconstruction of a bio-tooth 
      regarding the shape determination, size control, availability of dental 
      epithelium, directional growth and eruption, and graft rejection in the jaws 
      remain to be resolved. Here, this review outlines the current approaches toward 
      the tooth regeneration, and focuses on several key challenges that must be met in 
      the making of a bio-tooth.
FAU - Yu, Jinhua
AU  - Yu J
AD  - Institute of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, P.R. 
      China.
FAU - Shi, Junnan
AU  - Shi J
FAU - Jin, Yan
AU  - Jin Y
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Tissue Eng Part B Rev
JT  - Tissue engineering. Part B, Reviews
JID - 101466660
SB  - IM
MH  - Cell Culture Techniques/methods
MH  - Epithelial Cells/cytology/physiology
MH  - Graft Rejection/prevention & control
MH  - Humans
MH  - Mesoderm/cytology/physiology
MH  - Molecular Biology
MH  - Morphogenesis/*physiology
MH  - Odontogenesis/*physiology
MH  - Organ Culture Techniques/*methods
MH  - Regeneration/*physiology
MH  - Stem Cells/cytology/physiology
MH  - Tissue Engineering/*methods
MH  - Tooth/growth & development/physiology/surgery/*transplantation
MH  - Tooth Germ/cytology/physiology
RF  - 102
EDAT- 2008/07/31 09:00
MHDA- 2009/09/17 06:00
CRDT- 2008/07/31 09:00
PHST- 2008/07/31 09:00 [pubmed]
PHST- 2009/09/17 06:00 [medline]
PHST- 2008/07/31 09:00 [entrez]
AID - 10.1089/ten.teb.2008.0165 [pii]
AID - 10.1089/ten.teb.2008.0165 [doi]
PST - ppublish
SO  - Tissue Eng Part B Rev. 2008 Sep;14(3):307-19. doi: 10.1089/ten.teb.2008.0165.