PMID- 18665934
OWN - NLM
STAT- MEDLINE
DCOM- 20080908
LR  - 20220316
IS  - 1523-5378 (Electronic)
IS  - 1083-4389 (Linking)
VI  - 13
IP  - 4
DP  - 2008 Aug
TI  - The effects of probiotics on PPI-triple therapy for Helicobacter pylori 
      eradication.
PG  - 261-8
LID - 10.1111/j.1523-5378.2008.00601.x [doi]
AB  - BACKGROUND: This study was performed to evaluate whether the addition of 
      probiotics to proton pump inhibitor (PPI)-based triple therapy increases the 
      likelihood of successful Helicobacter pylori eradication. MATERIALS AND METHODS: 
      Three hundred and forty-seven H. pylori-infected patients were randomized into a 
      triple-plus-yogurt group (yogurt group, n = 168) or a triple-only group (control 
      group, n = 179). Triple therapy consisted of PPI b.i.d., clarithromycin 500 mg 
      b.i.d., and amoxicillin 1 g b.i.d. for 7 days. Yogurt group received triple 
      therapy for 1 week and one bottle of Will yogurt per day for at 3 weeks, starting 
      on the first day of triple therapy. Will yogurt (a Korean brand) contains 
      Lactobacillus acidophilus HY2177, Lactobacillus casei HY2743, Bifidobacterium 
      longum HY8001, and Streptococcus thermophilus B-1. (13)C-urea breath test was 
      performed at least 4 weeks after completion of triple therapy. Eradication rates, 
      compliances, and adverse events were compared. RESULTS: By intention-to treat 
      analysis the H. pylori eradication rates in the yogurt group 79.2% (133 of 168) 
      was similar to that in the control group 72.1% (129 of 179) (p = .124). However, 
      by per-protocol (PP) analysis, the eradication rate in the yogurt group, 87.5% 
      (133 of 152) was higher than that in the control group, 78.7% (129 of 164) (p = 
      .037). Common adverse events were metallic taste (11.8%) and diarrhea (8.6%). The 
      frequency of adverse effects in the yogurt group 41.1% (69/168) were higher than 
      in the control group, 26.3% (47 of 179) (p = .003). However, most adverse events 
      were mild to moderate in intensity, and the severities of adverse effects were 
      similar in both groups (p = .401). CONCLUSIONS: The addition of Will yogurt to 
      triple therapy did not reduce the side-effects of triple therapy. But it 
      increased the H. pylori eradication rate by PP analysis, encouraging more 
      research in this field.
FAU - Kim, Mi Na
AU  - Kim MN
AD  - Department of Internal Medicine and Liver Research Institute, Seoul National 
      University College of Medicine, Seoul, South Korea.
FAU - Kim, Nayoung
AU  - Kim N
FAU - Lee, Sang Hyup
AU  - Lee SH
FAU - Park, Young Soo
AU  - Park YS
FAU - Hwang, Jin-Hyeok
AU  - Hwang JH
FAU - Kim, Jin-Wook
AU  - Kim JW
FAU - Jeong, Sook-Hyang
AU  - Jeong SH
FAU - Lee, Dong Ho
AU  - Lee DH
FAU - Kim, Joo Sung
AU  - Kim JS
FAU - Jung, Hyun Chae
AU  - Jung HC
FAU - Song, In Sung
AU  - Song IS
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Helicobacter
JT  - Helicobacter
JID - 9605411
RN  - 0 (Proton Pump Inhibitors)
RN  - 804826J2HU (Amoxicillin)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amoxicillin/administration & dosage/adverse effects
MH  - Breath Tests
MH  - Clarithromycin/administration & dosage/adverse effects
MH  - Drug Therapy, Combination
MH  - Female
MH  - Helicobacter Infections/*drug therapy/microbiology
MH  - Helicobacter pylori/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Probiotics/*therapeutic use
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*administration & dosage/adverse effects
MH  - Yogurt/*microbiology
EDAT- 2008/07/31 09:00
MHDA- 2008/09/09 09:00
CRDT- 2008/07/31 09:00
PHST- 2008/07/31 09:00 [pubmed]
PHST- 2008/09/09 09:00 [medline]
PHST- 2008/07/31 09:00 [entrez]
AID - HEL601 [pii]
AID - 10.1111/j.1523-5378.2008.00601.x [doi]
PST - ppublish
SO  - Helicobacter. 2008 Aug;13(4):261-8. doi: 10.1111/j.1523-5378.2008.00601.x.