PMID- 18666810
OWN - NLM
STAT- MEDLINE
DCOM- 20080916
LR  - 20080731
IS  - 0033-7587 (Print)
IS  - 0033-7587 (Linking)
VI  - 170
IP  - 2
DP  - 2008 Aug
TI  - Terahertz radiation increases genomic instability in human lymphocytes.
PG  - 224-34
LID - 10.1667/RR0944.1 [doi]
AB  - Terahertz radiation is increasingly being applied in new and evolving 
      technologies applied in areas such as homeland security and medical imaging. Thus 
      a timely assessment of the potential hazards and health effects of occupational 
      and general population exposure to THz radiation is required. We applied 
      continuous-wave (CW) 0.1 THz radiation (0.031 mW/ cm(2)) to dividing lymphocytes 
      for 1, 2 and 24 h and examined the changes in chromosome number of chromosomes 1, 
      10, 11 and 17 and changes in the replication timing of their centromeres using 
      interphase fluorescence in situ hybridization (FISH). Chromosomes 11 and 17 were 
      most vulnerable (about 30% increase in aneuploidy after 2 and 24 h of exposure), 
      while chromosomes 1 and 10 were not affected. We observed changes in the 
      asynchronous mode of replication of centromeres 11, 17 and 1 (by 40%) after 2 h 
      of exposure and of all four centromeres after 24 h of exposure (by 50%). It is 
      speculated that these effects are caused by radiation-induced low-frequency 
      collective vibrational modes of proteins and DNA. Our results demonstrate that 
      exposure of lymphocytes in vitro to a low power density of 0.1 THz radiation 
      induces genomic instability. These findings, if verified, may suggest that such 
      exposure may result in an increased risk of cancer.
FAU - Korenstein-Ilan, Avital
AU  - Korenstein-Ilan A
AD  - Department of Physiology and Pharmacology, Faculty of Medicine, Tel-Aviv 
      University, Tel-Aviv, Israel. korens@post.tau.ac.il
FAU - Barbul, Alexander
AU  - Barbul A
FAU - Hasin, Pini
AU  - Hasin P
FAU - Eliran, Alon
AU  - Eliran A
FAU - Gover, Avraham
AU  - Gover A
FAU - Korenstein, Rafi
AU  - Korenstein R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
SB  - IM
MH  - Adult
MH  - Cells, Cultured
MH  - Dose-Response Relationship, Radiation
MH  - Genome, Human/*genetics/*radiation effects
MH  - Genomic Instability/*genetics/*radiation effects
MH  - Humans
MH  - Infrared Rays
MH  - Male
MH  - Microwaves
MH  - Middle Aged
MH  - Radiation Dosage
EDAT- 2008/08/01 09:00
MHDA- 2008/09/17 09:00
CRDT- 2008/08/01 09:00
PHST- 2007/01/03 00:00 [received]
PHST- 2008/03/12 00:00 [accepted]
PHST- 2008/08/01 09:00 [pubmed]
PHST- 2008/09/17 09:00 [medline]
PHST- 2008/08/01 09:00 [entrez]
AID - RR0944 [pii]
AID - 10.1667/RR0944.1 [doi]
PST - ppublish
SO  - Radiat Res. 2008 Aug;170(2):224-34. doi: 10.1667/RR0944.1.