PMID- 18667837
OWN - NLM
STAT- MEDLINE
DCOM- 20081118
LR  - 20211020
IS  - 1660-2110 (Electronic)
IS  - 1660-8151 (Print)
IS  - 1660-2110 (Linking)
VI  - 110
IP  - 1
DP  - 2008
TI  - Long-term efficacy and safety profile of lanthanum carbonate: results for up to 6 
      years of treatment.
PG  - c15-23
LID - 10.1159/000149239 [doi]
AB  - BACKGROUND/AIMS: Lanthanum carbonate (LC, FOSRENOL) is an effective phosphate 
      binder for which tolerability and a safety profile have been reported in 
      haemodialysis patients. Patients from previous studies entered a 2-year 
      extension, enabling assessment of efficacy and safety for up to 6 years of LC 
      monotherapy. METHODS: Patients from four previous trials entered this study. 
      RESULTS: Ninety-three patients started the extension, with 22 entering a sixth 
      year of LC treatment. Two-thirds of all patients received LC doses of 2,250 or 
      3,000 mg/day. Reductions in serum phosphate and calcium x phosphate product were 
      maintained for up to 6 years. There were no new or unexpected adverse events 
      (AEs), and no increase in the incidence of events with increasing treatment 
      exposure. Over the complete duration of therapy, treatment-related AEs occurred 
      in 25.8% of patients and were primarily gastrointestinal in nature. No clinically 
      relevant changes in liver function tests were observed and there was no evidence 
      of adverse effects on the liver, bone or the central nervous system. CONCLUSIONS: 
      LC monotherapy was effective and well tolerated for up to 6 years with no 
      evidence of safety concerns or increased frequency of AEs.
CI  - Copyright 2008 S. Karger AG, Basel.
FAU - Hutchison, Alastair J
AU  - Hutchison AJ
AD  - Manchester Royal Infirmary, Manchester, UK. alastair.hutchison@cmmc.nhs.uk
FAU - Barnett, M Edwina
AU  - Barnett ME
FAU - Krause, Rolfdieter
AU  - Krause R
FAU - Kwan, Jonathan T C
AU  - Kwan JT
FAU - Siami, Ghodrat A
AU  - Siami GA
CN  - SPD405-309 Lanthanum Study Group
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080731
PL  - Switzerland
TA  - Nephron Clin Pract
JT  - Nephron. Clinical practice
JID - 101159763
RN  - 0 (Phosphates)
RN  - 27YLU75U4W (Phosphorus)
RN  - 490D9F069T (lanthanum carbonate)
RN  - 6I3K30563S (Lanthanum)
SB  - IM
EIN - Nephron Clin Pract. 2008;110(1):c23
MH  - Adult
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hyperphosphatemia/*drug therapy/etiology/metabolism
MH  - Kidney Failure, Chronic/blood/complications/therapy
MH  - Lanthanum/administration & dosage/*adverse effects/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Phosphates/blood/metabolism
MH  - Phosphorus/blood/metabolism
MH  - Treatment Outcome
PMC - PMC2790759
FIR - Maes, B
IR  - Maes B
FIR - Musselmann, L
IR  - Musselmann L
FIR - Bagnewski, W
IR  - Bagnewski W
FIR - Meyer, E
IR  - Meyer E
FIR - Backs, W
IR  - Backs W
FIR - Schupp, J
IR  - Schupp J
FIR - Krause, R
IR  - Krause R
FIR - Prager, G
IR  - Prager G
FIR - Scholz, R
IR  - Scholz R
FIR - Asmus, G
IR  - Asmus G
FIR - Kirchertz, E J
IR  - Kirchertz EJ
FIR - Bohm, R
IR  - Bohm R
FIR - Cangiano, J
IR  - Cangiano J
FIR - Bradley, J
IR  - Bradley J
FIR - Hutchison, A J
IR  - Hutchison AJ
FIR - Kwan, J
IR  - Kwan J
FIR - Apantaku, F
IR  - Apantaku F
FIR - Barnett, M E
IR  - Barnett ME
FIR - Boren, K
IR  - Boren K
FIR - Kirchner, L
IR  - Kirchner L
FIR - Frederickson, E
IR  - Frederickson E
FIR - Germain, M
IR  - Germain M
FIR - Kaplan, M
IR  - Kaplan M
FIR - Keightley, G
IR  - Keightley G
FIR - Kopyt, N
IR  - Kopyt N
FIR - Locay, H
IR  - Locay H
FIR - Marin, P
IR  - Marin P
FIR - Mawad, H
IR  - Mawad H
FIR - Middleton, J
IR  - Middleton J
FIR - Mosset, R
IR  - Mosset R
FIR - Osorio, F
IR  - Osorio F
FIR - Qami, A
IR  - Qami A
FIR - Siami, G
IR  - Siami G
FIR - Steed, L
IR  - Steed L
FIR - Tokatlian, E
IR  - Tokatlian E
FIR - Weinberg, M
IR  - Weinberg M
FIR - Weise, W
IR  - Weise W
EDAT- 2008/08/01 09:00
MHDA- 2008/11/19 09:00
PMCR- 2008/07/31
CRDT- 2008/08/01 09:00
PHST- 2007/12/21 00:00 [received]
PHST- 2008/06/04 00:00 [accepted]
PHST- 2008/08/01 09:00 [pubmed]
PHST- 2008/11/19 09:00 [medline]
PHST- 2008/08/01 09:00 [entrez]
PHST- 2008/07/31 00:00 [pmc-release]
AID - 000149239 [pii]
AID - nec0110-0c15 [pii]
AID - 10.1159/000149239 [doi]
PST - ppublish
SO  - Nephron Clin Pract. 2008;110(1):c15-23. doi: 10.1159/000149239. Epub 2008 Jul 31.