PMID- 18667930
OWN - NLM
STAT- MEDLINE
DCOM- 20080919
LR  - 20200930
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 49
IP  - 1
DP  - 2008 Sep 1
TI  - Influence of HAART on the clinical course of HIV-1-infected patients with 
      progressive multifocal leukoencephalopathy: results of an observational 
      multicenter study.
PG  - 26-31
LID - 10.1097/QAI.0b013e31817bec64 [doi]
AB  - BACKGROUND: The aim of this study was to analyze the incidence of new cases, 
      survival of HIV-1-infected patients with progressive multifocal 
      leukoencephalopathy (PML), and the characteristics of PML-associated immune 
      reconstitution inflammatory syndrome (IRIS). METHODS: Multicenter observational 
      cohort study of all HIV-1-infected patients newly diagnosed of PML in 7 hospitals 
      in Barcelona (Spain) from 2002 to 2006. The annual incidence of PML was 
      calculated. Survival was estimated using the Kaplan-Meier method. IRIS was 
      defined as new onset or rapid worsening of PML shortly after initiation of highly 
      active antiretroviral therapy together with a decline in HIV-1 viral load and 
      rising of CD4 lymphocytes. RESULTS: Sixty-one new cases of PML were diagnosed. 
      The mean survival time was 15 months [95% confidence interval (CI), 11 to 19]. 
      The Kaplan-Meier estimates of the probability of survival were 47.7% (95% CI, 35 
      to 59) at 6 months, 38.6% (95% CI, 25 to 51) at 12 months, 35.1% (95% CI, 22 to 
      48) at 24 months, and 25.1% (95% CI, 10 to 40) at 36 months. IRIS was diagnosed 
      in 14 (23%) cases. Mortality was similar in patients with and without IRIS. 
      CONCLUSIONS: PML continues to be one of the deadliest opportunistic infections in 
      acquired immunodeficiency syndrome patients. The development of PML-associated 
      IRIS has no influence on prognosis.
FAU - Falco, Vicenc
AU  - Falco V
AD  - Infectious Disease Department, Hospital Universitario Vall d'Hebron, Barcelona, 
      Spain. vfalco@vhebron.net
FAU - Olmo, Montserrat
AU  - Olmo M
FAU - del Saz, Sara Villar
AU  - del Saz SV
FAU - Guelar, Ana
AU  - Guelar A
FAU - Santos, Jose R
AU  - Santos JR
FAU - Gutierrez, Mar
AU  - Gutierrez M
FAU - Colomer, Daniel
AU  - Colomer D
FAU - Deig, Elisabet
AU  - Deig E
FAU - Mateo, Gracia
AU  - Mateo G
FAU - Montero, Milagro
AU  - Montero M
FAU - Pedrol, Enric
AU  - Pedrol E
FAU - Podzamczer, Daniel
AU  - Podzamczer D
FAU - Domingo, Pere
AU  - Domingo P
FAU - Llibre, Josep M
AU  - Llibre JM
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*complications
MH  - Adult
MH  - *Antiretroviral Therapy, Highly Active
MH  - Cohort Studies
MH  - Female
MH  - HIV Infections/*complications/*drug therapy/mortality
MH  - *HIV-1
MH  - Humans
MH  - Immune System Diseases/complications/mortality
MH  - Leukoencephalopathy, Progressive Multifocal/*complications/mortality
MH  - Male
MH  - Middle Aged
MH  - Survival Analysis
EDAT- 2008/08/01 09:00
MHDA- 2008/09/20 09:00
CRDT- 2008/08/01 09:00
PHST- 2008/08/01 09:00 [pubmed]
PHST- 2008/09/20 09:00 [medline]
PHST- 2008/08/01 09:00 [entrez]
AID - 10.1097/QAI.0b013e31817bec64 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2008 Sep 1;49(1):26-31. doi: 
      10.1097/QAI.0b013e31817bec64.