PMID- 18668156
OWN - NLM
STAT- MEDLINE
DCOM- 20081219
LR  - 20211020
IS  - 1673-7067 (Print)
IS  - 1995-8218 (Electronic)
IS  - 1995-8218 (Linking)
VI  - 24
IP  - 4
DP  - 2008 Aug
TI  - Beneficial effects of moderate voluntary physical exercise and its biological 
      mechanisms on brain health.
PG  - 265-70
LID - 10.1007/s12264-008-0402-1 [doi]
AB  - This article reviewed the beneficial effects of moderate voluntary physical 
      exercise on brain health according to the studies on humans and animals, which 
      includes improving psychological status and cognitive function, enhancing 
      psychological well-being, decreasing the risks of Alzheimer's disease (AD) and 
      dementia, and promoting the effects of antidepressant and anxiolytic. The 
      possible underlying neurobiological mechanisms are involved up-active and 
      down-active pathways. The up-active pathway is associated with enhancements of 
      several neurotransmitters systems afferent to hippocampus, including 
      norepinephrine (NE), serotonin (5-Hydroxytryptamine, 5-HT), acetylcholine (ACh) 
      and gamma-aminobutyric acid (GABA). The down-active pathway is mainly concerned 
      with up-regulation of the brain-derived neurotrophic factor (BDNF) and 
      neurogenesis. It is suggested that NE activation via beta-adrenergic receptors 
      may be essential for exercise-induced BDNF up-regulation. The possible 
      intracellular signaling pathways of NE-mediated BDNF up-expression may be 
      involved in GPCR-MAPK-PI-3K crosstalk and positive feedback.
FAU - Ma, Qiang
AU  - Ma Q
AD  - Institute of Health and Environmental Medicine, Academy of Military Medical 
      Science, Tianjin, China.maqiangw@sina.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
RN  - 0 (Neurotransmitter Agents)
SB  - IM
MH  - Alzheimer Disease/prevention & control
MH  - Animals
MH  - Brain/*physiology
MH  - Dementia/prevention & control
MH  - Exercise/*physiology
MH  - Humans
MH  - Neurotransmitter Agents/metabolism
MH  - Physical Conditioning, Animal/physiology
MH  - Signal Transduction/*physiology
PMC - PMC5552589
EDAT- 2008/08/01 09:00
MHDA- 2008/12/20 09:00
PMCR- 2009/08/01
CRDT- 2008/08/01 09:00
PHST- 2008/08/01 09:00 [pubmed]
PHST- 2008/12/20 09:00 [medline]
PHST- 2008/08/01 09:00 [entrez]
PHST- 2009/08/01 00:00 [pmc-release]
AID - 402 [pii]
AID - 10.1007/s12264-008-0402-1 [doi]
PST - ppublish
SO  - Neurosci Bull. 2008 Aug;24(4):265-70. doi: 10.1007/s12264-008-0402-1.