PMID- 18671735
OWN - NLM
STAT- MEDLINE
DCOM- 20090305
LR  - 20211020
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 28
IP  - 5
DP  - 2008 Sep
TI  - The brain-derived neurotrophic factor receptor TrkB is critical for the 
      acquisition but not expression of conditioned incentive value.
PG  - 997-1002
LID - 10.1111/j.1460-9568.2008.06383.x [doi]
AB  - Stimuli paired with reward acquire incentive properties that are important for 
      many aspects of motivated behavior, such as feeding and drug-seeking. Here we 
      used a novel chemical-genetic strategy to determine the role of the brain-derived 
      neurotrophic factor (BDNF) receptor TrkB, known to be critical to many aspects of 
      neural development and plasticity, during acquisition and expression of positive 
      incentive value by a cue paired with food. We assessed that cue's learned 
      incentive value in a conditioned reinforcement task, in which its ability to 
      reinforce instrumental responding later, in the absence of food itself, was 
      examined. In TrkB (F616A) knock-in mice, TrkB kinase activity was suppressed by 
      administering the TrkB inhibitor 1NMPP1 during the period of initial cue 
      incentive learning only (i.e. Pavlovian training), during nose-poke conditioned 
      reinforcement testing only, during both phases, or during neither phase. All mice 
      acquired cue-food associations as indexed by approach responses. However, TrkB 
      (F616A) mice that received 1NMPP1 during initial cue incentive learning failed to 
      show conditioned reinforcement of nose-poking, regardless of their treatment in 
      testing, whereas administration of 1NMMP1 only during the testing phase had no 
      effect. The effects of 1NMPP1 administration were due to inhibition of 
      TrkB(F616A), because the performance of wild-type mice was unaffected by 
      administration of the compound during either phase. These data indicate that BDNF 
      or NT4 signaling through TrkB receptors is required for the acquisition of 
      positive incentive value, but is not needed for the expression of previously 
      acquired incentive value in the reinforcement of instrumental behavior.
FAU - Johnson, Alexander W
AU  - Johnson AW
AD  - Department of Psychological and Brain Sciences, Neurogenetics and Behavior 
      Center, Johns Hopkins University, Baltimore, MD 21218, USA. awj@jhu.edu
FAU - Chen, Xi
AU  - Chen X
FAU - Crombag, Hans S
AU  - Crombag HS
FAU - Zhang, Chao
AU  - Zhang C
FAU - Smith, Dani R
AU  - Smith DR
FAU - Shokat, Kevan M
AU  - Shokat KM
FAU - Gallagher, Michela
AU  - Gallagher M
FAU - Holland, Peter C
AU  - Holland PC
FAU - Ginty, David D
AU  - Ginty DD
LA  - eng
GR  - P40 RR017688/RR/NCRR NIH HHS/United States
GR  - RR017688/RR/NCRR NIH HHS/United States
GR  - P40 RR017688-04/RR/NCRR NIH HHS/United States
GR  - R37 NS034814/NS/NINDS NIH HHS/United States
GR  - R37 NS034814-13/NS/NINDS NIH HHS/United States
GR  - NS34814/NS/NINDS NIH HHS/United States
GR  - AI044009/AI/NIAID NIH HHS/United States
GR  - R01 NS034814/NS/NINDS NIH HHS/United States
GR  - R01 AI044009-10/AI/NIAID NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - R01 AI044009/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080726
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Nerve Growth Factors)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Conditioning, Psychological/drug effects/*physiology
MH  - Cues
MH  - Enzyme Inhibitors/pharmacology
MH  - Feeding Behavior/drug effects/physiology
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - *Motivation
MH  - Nerve Growth Factors/metabolism
MH  - Neuropsychological Tests
MH  - Receptor, trkB/antagonists & inhibitors/genetics/*metabolism
MH  - Reward
MH  - Signal Transduction/drug effects/physiology
PMC - PMC2825165
MID - NIHMS161247
EDAT- 2008/08/02 09:00
MHDA- 2009/03/06 09:00
PMCR- 2010/02/19
CRDT- 2008/08/02 09:00
PHST- 2008/08/02 09:00 [pubmed]
PHST- 2009/03/06 09:00 [medline]
PHST- 2008/08/02 09:00 [entrez]
PHST- 2010/02/19 00:00 [pmc-release]
AID - EJN6383 [pii]
AID - 10.1111/j.1460-9568.2008.06383.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2008 Sep;28(5):997-1002. doi: 10.1111/j.1460-9568.2008.06383.x. 
      Epub 2008 Jul 26.