PMID- 18672032
OWN - NLM
STAT- MEDLINE
DCOM- 20090206
LR  - 20211020
IS  - 0306-4522 (Print)
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 155
IP  - 4
DP  - 2008 Sep 9
TI  - BDNF-exercise interactions in the recovery of symmetrical stepping after a 
      cervical hemisection in rats.
PG  - 1070-8
LID - 10.1016/j.neuroscience.2008.06.057 [doi]
AB  - Clinical evidence indicates that motor training facilitates functional recovery 
      after a spinal cord injury (SCI). Brain-derived neurotrophic factor (BDNF) is a 
      powerful synaptic facilitator and likely plays a key role in motor and sensory 
      functions. Spinal cord hemisection decreases the levels of BDNF below the injury 
      site, and exercise can counteract this decrease [Ying Z, Roy RR, Edgerton VR, 
      Gomez-Pinilla F (2005) Exercise restores levels of neurotrophins and synaptic 
      plasticity following spinal cord injury. Exp Neurol 193:411-419]. It is not 
      clear, however, whether the exercise-induced increases in BDNF play a role in 
      mediating the recovery of locomotion after a SCI. We performed a lateral cervical 
      ( approximately C4) hemisection in adult rats. Seven days after hemisection, the 
      BDNF inhibitor trkB IgG was injected into the cervical spinal cord below the 
      lesion ( approximately C5-C6). Half of the rats were exposed to voluntary running 
      wheels for 14 days. Locomotor ability was assessed by determining the symmetry 
      between the contralateral (unaffected) vs. the ipsilateral (affected) forelimb at 
      the most optimum treadmill speed for each rat. Sedentary and exercised rats with 
      BDNF inhibition showed a higher level of asymmetry during the treadmill 
      locomotion test than rats not treated with the BDNF inhibitor. In hemisected 
      rats, exercise normalized the levels of molecules important for synaptic 
      function, such as cyclic AMP response element binding protein (CREB) and synapsin 
      I, in the ipsilateral cervical enlargement, whereas the BDNF blocker lessened 
      these exercise-associated effects. The results indicate that BDNF levels play an 
      important role in shaping the synaptic plasticity and in defining the level of 
      recovery of locomotor performance after a SCI.
FAU - Ying, Z
AU  - Ying Z
AD  - Department of Physiological Science, University of California, Los Angeles, CA 
      90095-1527, USA.
FAU - Roy, R R
AU  - Roy RR
FAU - Zhong, H
AU  - Zhong H
FAU - Zdunowski, S
AU  - Zdunowski S
FAU - Edgerton, V R
AU  - Edgerton VR
FAU - Gomez-Pinilla, F
AU  - Gomez-Pinilla F
LA  - eng
GR  - R01 NS050465-04/NS/NINDS NIH HHS/United States
GR  - P01 NS016333/NS/NINDS NIH HHS/United States
GR  - NS16333/NS/NINDS NIH HHS/United States
GR  - R01 NS050465/NS/NINDS NIH HHS/United States
GR  - NS50465/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080703
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GAP-43 Protein)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Synapsins)
RN  - 0 (neurotropin 3, mouse)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - CREB-Binding Protein/genetics/metabolism
MH  - Exercise Test
MH  - Functional Laterality/drug effects/physiology
MH  - GAP-43 Protein/genetics/metabolism
MH  - Humans
MH  - Immunoglobulin G/administration & dosage
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - Nerve Growth Factors/genetics/metabolism
MH  - Physical Conditioning, Animal/*methods
MH  - Psychomotor Performance/drug effects/*physiology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/immunology
MH  - Recovery of Function/drug effects/*physiology
MH  - Spinal Cord Injuries/*physiopathology/*rehabilitation
MH  - Synapsins/genetics/metabolism
MH  - Weight-Bearing/physiology
PMC - PMC2805664
MID - NIHMS69697
EDAT- 2008/08/02 09:00
MHDA- 2009/02/07 09:00
PMCR- 2010/01/12
CRDT- 2008/08/02 09:00
PHST- 2008/02/14 00:00 [received]
PHST- 2008/06/07 00:00 [revised]
PHST- 2008/06/28 00:00 [accepted]
PHST- 2008/08/02 09:00 [pubmed]
PHST- 2009/02/07 09:00 [medline]
PHST- 2008/08/02 09:00 [entrez]
PHST- 2010/01/12 00:00 [pmc-release]
AID - S0306-4522(08)00984-6 [pii]
AID - 10.1016/j.neuroscience.2008.06.057 [doi]
PST - ppublish
SO  - Neuroscience. 2008 Sep 9;155(4):1070-8. doi: 10.1016/j.neuroscience.2008.06.057. 
      Epub 2008 Jul 3.