PMID- 18673338
OWN - NLM
STAT- MEDLINE
DCOM- 20081126
LR  - 20080929
IS  - 1524-4741 (Electronic)
IS  - 1075-122X (Linking)
VI  - 14
IP  - 5
DP  - 2008 Sep-Oct
TI  - Presence of a micropapillary pattern in mucinous carcinomas of the breast and its 
      impact on the clinical behavior.
PG  - 412-20
LID - 10.1111/j.1524-4741.2008.00616.x [doi]
AB  - Infiltrating micropapillary carcinomas (IMPC) of breast are highly angioinvasive 
      tumors with poor prognosis. This study is based on the observation that a similar 
      micropapillary pattern is also observed in mucinous carcinomas of breast. About 
      102 mucinous carcinomas were evaluated for the presence and impact of this 
      micropapillary pattern on the clinical behavior. Of these, 68 were mucinous 
      carcinomas with a micropapillary pattern (MUMPC), 20 had MUMPC mixed with an 
      infiltrating duct carcinoma component, two were solid variants of papillary 
      carcinoma with mucin (SVPCMU), five had collision of the MUMPC and SVPCMU 
      patterns and seven were mucinous carcinomas with signet ring cells (MUS). The 
      factors negatively affecting overall survival (OAS) and disease-free survival 
      (DFS) included the histological type of mucinous carcinoma, nodal metastases, an 
      irregular tumor border, <50% mucin and an IMPC type of local recurrence or 
      metastases. In the multivariate analysis, the histologic type of mucinous 
      carcinoma and an irregular tumor border were most significant for OAS and DFS. 
      Thus, 86% of mucinous carcinomas in this study were mucinous variants of the 
      angioinvasive infiltrating micropapillary carcinomas. These tumors can produce 
      IMPC type of metastases and thus should be treated aggressively.
FAU - Shet, Tanuja
AU  - Shet T
AD  - Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India. 
      tanujashet@yahoo.com
FAU - Chinoy, Roshni
AU  - Chinoy R
LA  - eng
PT  - Journal Article
DEP - 20080730
PL  - United States
TA  - Breast J
JT  - The breast journal
JID - 9505539
SB  - IM
MH  - Adenocarcinoma, Mucinous/mortality/pathology/*secondary
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Biopsy, Needle
MH  - Breast Neoplasms/mortality/*pathology
MH  - Carcinoma, Papillary/mortality/pathology/*secondary
MH  - Cohort Studies
MH  - Combined Modality Therapy
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Invasiveness
MH  - Neoplasm Recurrence, Local/mortality/*pathology
MH  - Neoplasm Staging
MH  - Probability
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Survival Analysis
EDAT- 2008/08/05 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/08/05 09:00
PHST- 2008/08/05 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/08/05 09:00 [entrez]
AID - TBJ616 [pii]
AID - 10.1111/j.1524-4741.2008.00616.x [doi]
PST - ppublish
SO  - Breast J. 2008 Sep-Oct;14(5):412-20. doi: 10.1111/j.1524-4741.2008.00616.x. Epub 
      2008 Jul 30.