PMID- 18674465
OWN - NLM
STAT- MEDLINE
DCOM- 20090917
LR  - 20170214
IS  - 1708-5381 (Print)
IS  - 1708-5381 (Linking)
VI  - 16
IP  - 3
DP  - 2008 May-Jun
TI  - Effects of enoxaparin and unfractionated heparin on platelet activity and 
      reactivity during carotid endarterectomy.
PG  - 161-6
AB  - The aim of this study was to determine platelet activity and reactivity and the 
      effects of unfractionated heparin (UFH) and enoxaparin on platelet function 
      during carotid eversion endarterectomy under local anesthesia. Twenty symptomatic 
      patients undergoing carotid endarterectomy were randomly assigned to either 5,000 
      units of UFH or body weight-adjusted enoxaparin (0.5 mg/kg body weight) as an 
      intraoperative intravenous bolus. The activity of platelets was assessed by 
      measuring the expression of CD62p and CD41 with flow cytometry. Additionally, 
      platelet-leukocyte aggregates (PLAs) were enumerated. The reactivity of platelets 
      was evaluated by measuring the expression of the same antigens after stimulation. 
      In addition, platelet reactivity was also analyzed using a PFA-100 analyzer. A 
      significant increase in platelet activity was observed during surgery for CD41 
      and CD62p (p = .002 and < .001, respectively). The number of PLAs showed no 
      significant changes during surgery. Yet there was a significant difference 
      between patients treated with UFH and patients treated with enoxaparin. No 
      difference for platelet activity or reactivity for patients receiving either UFH 
      or enoxaparin prior to cross-clamping of the carotid arteries was seen. The 
      formation of PLAs after endarterectomy was significantly higher in the UFH group; 
      thus, PLAs are probably a useful surrogate parameter for measuring platelet 
      activity.
FAU - Assadian, Afshin
AU  - Assadian A
AD  - Department of General and Vascular Surgery, Wilhelminenspital Vienna, Austria. 
      afshin_assadian@yahoo.de
FAU - Senekowitsch, Christian
AU  - Senekowitsch C
FAU - Hagmuller, Georg W
AU  - Hagmuller GW
FAU - Lax, Jaqueline
AU  - Lax J
FAU - Hubl, Wolfgang
AU  - Hubl W
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Vascular
JT  - Vascular
JID - 101196722
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
RN  - 0 (P-Selectin)
RN  - 0 (Platelet Membrane Glycoprotein IIb)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Aged
MH  - Anesthesia, Local
MH  - Anticoagulants/*pharmacology
MH  - Blood Platelets/*drug effects
MH  - Carotid Artery, Internal/surgery
MH  - Carotid Stenosis/blood/surgery
MH  - *Endarterectomy, Carotid
MH  - Enoxaparin/pharmacology
MH  - Female
MH  - Heparin/*pharmacology
MH  - Humans
MH  - Intraoperative Care/methods
MH  - Male
MH  - Middle Aged
MH  - P-Selectin/blood
MH  - Platelet Aggregation/drug effects
MH  - Platelet Function Tests/methods
MH  - Platelet Membrane Glycoprotein IIb/blood
EDAT- 2008/08/05 09:00
MHDA- 2009/09/18 06:00
CRDT- 2008/08/05 09:00
PHST- 2008/08/05 09:00 [pubmed]
PHST- 2009/09/18 06:00 [medline]
PHST- 2008/08/05 09:00 [entrez]
AID - 10.2310/6670.2008.00028 [doi]
PST - ppublish
SO  - Vascular. 2008 May-Jun;16(3):161-6. doi: 10.2310/6670.2008.00028.