PMID- 18675506
OWN - NLM
STAT- MEDLINE
DCOM- 20081028
LR  - 20081013
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 271
IP  - 2
DP  - 2008 Nov 28
TI  - Vaccination with transforming growth factor-beta insensitive dendritic cells 
      suppresses pulmonary metastases of renal carcinoma in mice.
PG  - 333-41
LID - 10.1016/j.canlet.2008.06.025 [doi]
AB  - Dendritic cells (DCs) have been widely used as cancer vaccines. However, their 
      functional abilities have often been suppressed by tumor-secreted 
      immunosuppressants such as transforming growth factor-beta (TGF-beta). We 
      developed a new strategy using a TGF-beta insensitive DC as cancer vaccine. The 
      effect of this vaccine was tested in a murine pulmonary metastases model of renal 
      carcinoma (Renca). Tumor lysate-pulsed DCs (TP-DCs) were infected with retrovirus 
      containing gene of dominant negative TGF-beta type II receptor (TbetaRIIDN) and 
      thus made TGF-beta insensitive. Vaccination of the mice bearing Renca pulmonary 
      metastases with the TbetaRIIDN TP-DC induced powerful tumor-specific cytotoxic T 
      lymphocyte (CTL) responses, suppressed pulmonary metastases, and prolonged 
      survival times. These results suggest TGF-beta-insensitive TP-DC vaccine can be 
      used to enhance the antitumor efficacy of DC vaccine.
FAU - Tian, Feng
AU  - Tian F
AD  - Department of Urology, Xijing Hospital, Fourth Military Medical University, 15 
      Chang Le West Road, Xi'an, Shaanxi Province 710032, China.
FAU - Wang, Longxin
AU  - Wang L
FAU - Qin, Weijun
AU  - Qin W
FAU - Wang, Fuli
AU  - Wang F
FAU - Song, Bin
AU  - Song B
FAU - Li, Yu
AU  - Li Y
FAU - Wen, Weihong
AU  - Wen W
FAU - Zhang, Zheng
AU  - Zhang Z
FAU - Zhu, Kaichang
AU  - Zhu K
FAU - Zhang, Qiang
AU  - Zhang Q
FAU - Lee, Chung
AU  - Lee C
FAU - Zhong, Weide
AU  - Zhong W
FAU - Guo, Yinglu
AU  - Guo Y
FAU - Wang, He
AU  - Wang H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Flow Cytometry
MH  - Kidney Neoplasms/immunology/*pathology
MH  - Lung Neoplasms/immunology/*secondary
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - Transforming Growth Factor beta/*immunology
EDAT- 2008/08/05 09:00
MHDA- 2008/10/29 09:00
CRDT- 2008/08/05 09:00
PHST- 2008/04/16 00:00 [received]
PHST- 2008/04/16 00:00 [revised]
PHST- 2008/06/23 00:00 [accepted]
PHST- 2008/08/05 09:00 [pubmed]
PHST- 2008/10/29 09:00 [medline]
PHST- 2008/08/05 09:00 [entrez]
AID - S0304-3835(08)00504-1 [pii]
AID - 10.1016/j.canlet.2008.06.025 [doi]
PST - ppublish
SO  - Cancer Lett. 2008 Nov 28;271(2):333-41. doi: 10.1016/j.canlet.2008.06.025.