PMID- 18675646
OWN - NLM
STAT- MEDLINE
DCOM- 20081126
LR  - 20131121
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 43
IP  - 8
DP  - 2008 Aug
TI  - Investigation of histopathologic changes in the ureter walls in experimental 
      congenital obstructive uropathy.
PG  - 1524-7
LID - 10.1016/j.jpedsurg.2007.11.025 [doi]
AB  - BACKGROUND/PURPOSE: The aim of this study is to determine the histopathologic 
      changes in the ureter wall in experimental urinary bladder hypoplasia and 
      agenesis. METHODS: Timed pregnant rats were randomly divided and received 
      intraperitoneal Adriamycin (ADR) at 2 mg/kg on gestational days (GD) 6 to 9 (ADR 
      group) and saline at 2 mL/kg on GD 6 to 9 (SF group). The control (C) group did 
      not receive any medication in their pregnancy. Fetuses were harvested near term 
      on GD 21 and dissected under a dissecting microscope and examined for urinary 
      system abnormalities. RESULTS: Diameter of ureter lumen was significantly 
      increased, but wall thickness, tunica muscularis, and epithelial thickness of the 
      ureter were decreased in the ADR group as compared with the C and SF groups. 
      CONCLUSIONS: Diameter of the ureter lumen was increased, but wall thickness, 
      tunica muscularis, and uroepithelium of the ureter were decreased in the ADR 
      group in the intrauterine period. The diameter of the ureter lumen and wall 
      thickness of ureter (tunica muscularis of ureter and uroepithelium) were 
      increased following obstructive uropathy after the birth.
FAU - Gurbuzer, Nilifer
AU  - Gurbuzer N
AD  - Department of Pediatric Surgery, Meram Medical School of Selcuk University, 42080 
      Konya, Turkey.
FAU - Yurtcu, Muslim
AU  - Yurtcu M
FAU - Findik, Siddika
AU  - Findik S
FAU - Avunduk, Mustafa Cihat
AU  - Avunduk MC
FAU - Gunel, Engin
AU  - Gunel E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Abnormalities, Drug-Induced/*pathology
MH  - Analysis of Variance
MH  - Animals
MH  - Biopsy, Needle
MH  - Disease Models, Animal
MH  - Doxorubicin/toxicity
MH  - Female
MH  - Immunohistochemistry
MH  - Pregnancy
MH  - Pregnancy, Animal
MH  - Probability
MH  - Random Allocation
MH  - Rats
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Ureter/*pathology
MH  - Ureteral Obstruction/congenital/*pathology
MH  - Urinary Bladder/*abnormalities/pathology
EDAT- 2008/08/05 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/08/05 09:00
PHST- 2007/09/18 00:00 [received]
PHST- 2007/11/07 00:00 [revised]
PHST- 2007/11/17 00:00 [accepted]
PHST- 2008/08/05 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/08/05 09:00 [entrez]
AID - S0022-3468(07)00914-1 [pii]
AID - 10.1016/j.jpedsurg.2007.11.025 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2008 Aug;43(8):1524-7. doi: 10.1016/j.jpedsurg.2007.11.025.