PMID- 18679013
OWN - NLM
STAT- MEDLINE
DCOM- 20081008
LR  - 20221207
IS  - 1349-3329 (Electronic)
IS  - 0040-8727 (Linking)
VI  - 215
IP  - 4
DP  - 2008 Aug
TI  - Novel mutations of mitochondrial DNA associated with type 2 diabetes in Chinese 
      Han population.
PG  - 377-84
AB  - Mitochondrial single nucleotide polymorphisms (mtSNPs) have been reported to 
      associate with type-2 diabetes mellitus (T2DM), but mtSNPs appear to be 
      considerably different among different populations and regions. To determine 
      mtSNPs in Chinese Han patients with T2DM, the entire sequences of the 
      mitochondrial genomes from 72 T2DM Chinese (59 +/- 4 years) and 50 age-matched 
      healthy subjects (controls) in Chongqing region of Western China were directly 
      sequenced and mtSNPs were analyzed. We found that M8, M9, D, G, R and A 
      haplogroups exist in Chinese Han population and the frequency of haplogroup M9 
      was significantly higher in patients with T2DM than in the controls (p = 0.0006, 
      OR 0.06 [95% CI 0.008-0.476]). MtSNPs T3394C in NADH dehydrogenase subunit 1 
      (ND1), G4491A in ND2, T16189C and T16519C were found with significantly higher 
      frequency in patients with T2DM than in the controls (T16189C, p = 0.0045; 
      T16519C, p < 0.0001; T3394C, p = 0.0015; G4491A, p = 0.0015). In contrast, the 
      frequency of C5178A in ND2 and A10398G in ND3 was higher in the controls than in 
      patients with T2DM (C5178A, p = 0.014; A10398G, p = 0.0011). Our results indicate 
      that mtSNPs T3394C, G4491A, T16189C and T16519C show susceptible tendency to T2DM 
      and mtSNPs C5178A and A10398G seem to be genetic factors for against T2DM. These 
      mtSNPs determined in our study is useful and could be used for early diagnosis 
      and prevention of T2DM in Chinese Han population.
FAU - Liao, Wen-Qiang
AU  - Liao WQ
AD  - Institute of Cardiovascular Medicine, National Integrative Medicine Centre for 
      Cardiovascular Disease, China-Japan Friendship Hospital, Beijing, China.
FAU - Pang, Yan
AU  - Pang Y
FAU - Yu, Chang-An
AU  - Yu CA
FAU - Wen, Jian-Yan
AU  - Wen JY
FAU - Zhang, Yi-Guan
AU  - Zhang YG
FAU - Li, Xiao-Hui
AU  - Li XH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (Blood Glucose)
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Mitochondrial)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
SB  - IM
MH  - Asian People/genetics
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - China
MH  - DNA Primers
MH  - DNA, Mitochondrial/*genetics
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Lipids/blood
MH  - Middle Aged
MH  - *Mutation
MH  - Outpatients
MH  - *Polymorphism, Single Nucleotide
MH  - Reference Values
EDAT- 2008/08/06 09:00
MHDA- 2008/10/09 09:00
CRDT- 2008/08/06 09:00
PHST- 2008/08/06 09:00 [pubmed]
PHST- 2008/10/09 09:00 [medline]
PHST- 2008/08/06 09:00 [entrez]
AID - JST.JSTAGE/tjem/215.377 [pii]
AID - 10.1620/tjem.215.377 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2008 Aug;215(4):377-84. doi: 10.1620/tjem.215.377.