PMID- 18679407
OWN - NLM
STAT- MEDLINE
DCOM- 20081219
LR  - 20180822
IS  - 0818-9641 (Print)
IS  - 0818-9641 (Linking)
VI  - 86
IP  - 7
DP  - 2008 Oct
TI  - Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune 
      responses.
PG  - 580-7
LID - 10.1038/icb.2008.55 [doi]
AB  - Dendritic cells (DCs) have an important function in the initiation and 
      differentiation of immune responses, linking innate information to tailored 
      adaptive responses. Depending on the pathogen invading the body, specific immune 
      responses are built up that are crucial for eliminating the pathogen from the 
      host. Host recognition of invading microorganisms relies on evolutionarily 
      ancient, germline-encoded pattern recognition receptors (PRRs) that are highly 
      expressed on the cell surface of DCs, of which the Toll-like receptors (TLRs) are 
      well characterized and recognize bacterial or viral components. Moreover, they 
      bind a variety of self-proteins released from damaged tissues including several 
      heat-shock proteins. The membrane-associated C-type lectin receptors (CLRs) 
      recognize glycan structures expressed by host cells of the immune system or on 
      specific tissues, which upon recognition allow cellular interactions between DCs 
      and other immune or tissue cells. In addition, CLRs can function as PRRs. In 
      contrast to TLRs, CLRs recognize carbohydrate structures present on the 
      pathogens. Modification of glycan structures on pathogens to mimic host glycans 
      can thereby alter CLR interactions that subsequently modifies DC-induced 
      polarization. In this review, we will discuss in detail how specific 
      glycosylation of antigens can dictate both the innate and adaptive interactions 
      that are mediated by CLRs on DCs and how this balances immune activation and 
      inhibition of DC function.
FAU - van Vliet, Sandra J
AU  - van Vliet SJ
AD  - Department of Molecular Cell Biology and Immunology, VU University Medical 
      Center, Amsterdam, The Netherlands.
FAU - Garcia-Vallejo, Juan J
AU  - Garcia-Vallejo JJ
FAU - van Kooyk, Yvette
AU  - van Kooyk Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080805
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
RN  - 0 (Lectins, C-Type)
RN  - 0 (Polysaccharides)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Gene Expression Regulation/immunology
MH  - Humans
MH  - *Immunity, Active
MH  - *Immunity, Innate
MH  - Lectins, C-Type/*immunology
MH  - Polysaccharides/immunology
RF  - 89
EDAT- 2008/08/06 09:00
MHDA- 2008/12/20 09:00
CRDT- 2008/08/06 09:00
PHST- 2008/08/06 09:00 [pubmed]
PHST- 2008/12/20 09:00 [medline]
PHST- 2008/08/06 09:00 [entrez]
AID - icb200855 [pii]
AID - 10.1038/icb.2008.55 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2008 Oct;86(7):580-7. doi: 10.1038/icb.2008.55. Epub 2008 Aug 
      5.