PMID- 18681284
OWN - NLM
STAT- MEDLINE
DCOM- 20090612
LR  - 20080806
IS  - 1002-1892 (Print)
IS  - 1002-1892 (Linking)
VI  - 22
IP  - 7
DP  - 2008 Jul
TI  - [The effects of fibrin glue on acute complete transection spinal cord injury].
PG  - 828-31
AB  - OBJECTIVE: To investigate the effects of fibrin glue on repair and regeneration 
      of acute complete spinal cord injury. METHODS: Acute complete transaction spinal 
      cord injury model were made in 10 adult healthy SD rats (female, weighing 250-300 
      g), randomized grouping: treated group (n=5) and control group (n=5). In the 
      treated group, fibrin glue was implanted covering on the injury site and filling 
      the lesion gap. In the control group, no treatment was given. At 4 weeks, the 
      locomotor functions of the rats were detected by basso, beattie and bresnahan 
      (BBB) score, then the means of immunohistochemistry were used to observe 
      neurofilament(NF) and glial fibrillary acidic protein(GFAP). And image analysis 
      was used to measure the quantify of the nerve fiber and the fibers area ratio of 
      astrocyte. RESULTS: The BBB scores were 2.40 +/- 0.51 in control group, 3.00 +/- 
      0.45 in treated group, showing no significant difference (P > 0.05). By 
      immunohistochemistry: a little positive NF cells and GFAP frame were found in 
      control group; more positive NF cells and GFAP frame were found in treated group, 
      the cells and frame grew toward the center but did not arrive at the center. 
      Image analysis showed the amount of never fibers in treated group (rostral 
      region: 113.10 +/- 20.75, caudal region: 73.60 +/- 33.61) was more than that in 
      control group (rostral region: 45.50 +/- 17.18, caudal region 23.50 +/- 8.20), 
      showing significant difference. The fibers area ratio of astrocyte in treated 
      group (rostral region: 33.75% +/- 11.06%, caudal region: 27.75% +/- 7.15%) was 
      more than that in control group(rostral region: 23.78% +/- 5.76%, caudal region: 
      19.78% +/- 5.17%), showing significant difference (P < 0.05). CONCLUSION: Fibrin 
      glue can promote repair and regeneration of acute spinal cord injury.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Neurosurgery, Beijing Chao Yang Hospital, Capital Medical 
      University, Beijing, 100020, PR China. drpatrick007@sina.com
FAU - Zhao, Qihuang
AU  - Zhao Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
JT  - Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = 
      Chinese journal of reparative and reconstructive surgery
JID - 9425194
RN  - 0 (Fibrin Tissue Adhesive)
RN  - 0 (Glial Fibrillary Acidic Protein)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Female
MH  - Fibrin Tissue Adhesive/*therapeutic use
MH  - Glial Fibrillary Acidic Protein/biosynthesis
MH  - Nerve Fibers/*physiology
MH  - *Nerve Regeneration
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord Injuries/*surgery
EDAT- 2008/08/07 09:00
MHDA- 2009/06/13 09:00
CRDT- 2008/08/07 09:00
PHST- 2008/08/07 09:00 [pubmed]
PHST- 2009/06/13 09:00 [medline]
PHST- 2008/08/07 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008 Jul;22(7):828-31.