PMID- 18683151
OWN - NLM
STAT- MEDLINE
DCOM- 20090402
LR  - 20080806
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 25
IP  - 4
DP  - 2008 Aug
TI  - [Identification of a novel allele human leukocyte antigen B*4609].
PG  - 459-61
AB  - OBJECTIVE: To identify a novel human leukocyte antigen (HLA) allele. METHODS: HLA 
      typing was carried out with PCR-SSOP. Molecular cloning and DNA sequencing were 
      used to identify the sequence of a potential novel allele and the difference 
      between this new allele and other known alleles was analyzed. RESULTS: HLA 
      genotyping of one sample gave different results. The sequencing results showed 
      that the HLA B alleles of the proband were B*151101 and a novel allele. The 
      nucleotide sequence of the novel allele was different from all other known B 
      alleles. It had one nucleotide change from the closest matching allele B*460101 
      at nucleotide 527 (A to T) in exon 3, resulting in an amino acid change from E 
      (GAG) to V (GTG) at codon 176. CONCLUSION: A novel HLA B allele was identified 
      and officially designated as HLA B*4609 by WHO Nomenclature Committee for Factors 
      of the HLA System in November, 2006.
FAU - Chen, Yang
AU  - Chen Y
AD  - Liaoning Blood Center, Shenyang, Liaoning, 110044 P. R. China. ljp_63@yahoo.com.
FAU - Li, Jian-ping
AU  - Li JP
FAU - Zhang, Kun-lian
AU  - Zhang KL
FAU - Zhang, Xu
AU  - Zhang X
FAU - Liu, Xian-zhi
AU  - Liu XZ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - *Alleles
MH  - Amino Acid Substitution
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - HLA Antigens/genetics/immunology
MH  - HLA-B Antigens/*genetics/immunology
MH  - Humans
MH  - Molecular Sequence Data
MH  - Polymorphism, Single Nucleotide
MH  - Sequence Homology, Nucleic Acid
EDAT- 2008/08/07 09:00
MHDA- 2009/04/03 09:00
CRDT- 2008/08/07 09:00
PHST- 2008/08/07 09:00 [pubmed]
PHST- 2009/04/03 09:00 [medline]
PHST- 2008/08/07 09:00 [entrez]
AID - 940625101 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008 Aug;25(4):459-61.