PMID- 18683155
OWN - NLM
STAT- MEDLINE
DCOM- 20090402
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 25
IP  - 4
DP  - 2008 Aug
TI  - [Study of the HLA-A, B, DRB1 allele and haplotype frequencies of 4194 cord blood 
      samples in Guangzhou].
PG  - 473-6
AB  - OBJECTIVE: To analyze the distribution of the human leukocyte antigen (HLA)-A, B 
      and DRB1 allele and haplotype in cord blood samples preserved in Guangzhou Cord 
      Blood Bank collected in the last 10 years. METHODS: The HLA-A, B and DRB1 
      genotyping of 4194 cord blood samples were detected by Special Monoclonal Tray, 
      PCR-sequence specific promer (PCR-SSP), PCR-sequence specific oligonucleotide 
      probe (PCR-SSO) and sequence based typing (SBT). Frequencies of HLA-A, B and DRB1 
      allele and haplotype were calculated by Arlequin software. RESULTS: The total 
      numbers of HLA-A, B and DRB1 alleles are 18, 43, 13 respectively. The obviously 
      high frequency alleles are A*11, A*02, A*24, A*33, B*40, B*15, B*46, B*13, 
      DRB1*12, DRB1*15, DRB1*09 and DRB1*04, with accumulative frequency of each locus 
      being more than 50%. The most common haplotypes are A2-B46, B46-DR9, A11-DR12 and 
      A2-B46-DR9. CONCLUSION: The distribution of HLA-A, B and DRB1 allele and 
      haplotype of cord blood in Guangzhou Cord Blood Bank has typical characteristics 
      of southern Chinese Han population. Authors' data may help in searching for 
      appropriate donors.
FAU - Sha, Wen-qiong
AU  - Sha WQ
AD  - Guangzhou Maternal and Fetal Hospital, Guangzhou Medical College, Guangzhou, 
      Guangdong, 510180 People's Republic of China.
FAU - Liao, Can
AU  - Liao C
FAU - Li, Yan
AU  - Li Y
FAU - Yang, Xin
AU  - Yang X
FAU - Tang, Xue-wei
AU  - Tang XW
FAU - Huang, Yi-ning
AU  - Huang YN
FAU - Xie, Xing-mei
AU  - Xie XM
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - *Alleles
MH  - Asian People/*genetics
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genetics, Population
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/genetics
MH  - Haplotypes
MH  - Humans
EDAT- 2008/08/07 09:00
MHDA- 2009/04/03 09:00
CRDT- 2008/08/07 09:00
PHST- 2008/08/07 09:00 [pubmed]
PHST- 2009/04/03 09:00 [medline]
PHST- 2008/08/07 09:00 [entrez]
AID - 940625105 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008 Aug;25(4):473-6.