PMID- 18684745
OWN - NLM
STAT- MEDLINE
DCOM- 20090126
LR  - 20211020
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Print)
IS  - 0003-4967 (Linking)
VI  - 68
IP  - 1
DP  - 2009 Jan
TI  - Non-inherited maternal human leukocyte antigen alleles in susceptibility to 
      familial rheumatoid arthritis.
PG  - 107-9
LID - 10.1136/ard.2008.092312 [doi]
AB  - OBJECTIVES: Some patients with rheumatoid arthritis (RA) lack RA-associated human 
      leukocyte antigen (HLA) alleles. Prior studies investigated non-inherited 
      maternal HLA alleles (NIMA) in RA risk with conflicting results. METHODS: We 
      examined NIMA in a large cohort of families from the North American Rheumatoid 
      Arthritis Consortium (NARAC). RESULTS: Among 620 patients with 1 or both parents 
      having a HLA genotype, patients with RA informative for analysis included 176 
      without HLA-DRB1*04 and 86 without the HLA shared epitope (SE). The frequency of 
      NIMA encoding HLA-DR4 or the SE was compared to the non-inherited paternal allele 
      (NIPA). DR4-encoding NIMA vs NIPA revealed no significant difference (27% vs 
      20%). However, parity is known to modulate RA risk and analyses stratified by sex 
      and age of onset showed significant variation among women. Interestingly, among 
      women with onset <45 years DR4-encoding NIMA was increased compared to NIPA; 
      among women > or =45 years at onset the reverse was observed (31% vs 16% compared 
      to 10% vs 60%, p = 0.008). DR4 encoding NIMA vs NIPA did not differ in men. The 
      SE did not differ in men or women. CONCLUSIONS: Risk of RA was associated with 
      HLA-DR4 encoding NIMA in younger-onset women but not in older-onset women or men. 
      These observations could help explain conflicting prior results of NIMA in RA.
FAU - Guthrie, K A
AU  - Guthrie KA
AD  - Clinical Statistics D5-360, Fred Hutchinson Cancer Research Center, Seattle, 
      Washington 98109-1024, USA. kguthrie@fhcrc.org
FAU - Tishkevich, N R
AU  - Tishkevich NR
FAU - Nelson, J L
AU  - Nelson JL
LA  - eng
GR  - N01AR22263/AR/NIAMS NIH HHS/United States
GR  - R01 AI045659/AI/NIAID NIH HHS/United States
GR  - R01 AI041721/AI/NIAID NIH HHS/United States
GR  - AI41721/AI/NIAID NIH HHS/United States
GR  - AI45659/AI/NIAID NIH HHS/United States
GR  - N01 AR22263/AR/NIAMS NIH HHS/United States
GR  - R01 AI045659-10/AI/NIAID NIH HHS/United States
GR  - R01 AI041721-12/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080806
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Alleles
MH  - Arthritis, Rheumatoid/*genetics/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Epitope Mapping/methods
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Mothers
MH  - Risk
MH  - Sex Factors
PMC - PMC2760537
MID - NIHMS135329
EDAT- 2008/08/08 09:00
MHDA- 2009/01/27 09:00
PMCR- 2009/10/12
CRDT- 2008/08/08 09:00
PHST- 2008/08/08 09:00 [entrez]
PHST- 2008/08/08 09:00 [pubmed]
PHST- 2009/01/27 09:00 [medline]
PHST- 2009/10/12 00:00 [pmc-release]
AID - ard.2008.092312 [pii]
AID - 10.1136/ard.2008.092312 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2009 Jan;68(1):107-9. doi: 10.1136/ard.2008.092312. Epub 2008 Aug 
      6.