PMID- 18685620
OWN - NLM
STAT- MEDLINE
DCOM- 20090227
LR  - 20220409
IS  - 1523-1747 (Electronic)
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 129
IP  - 2
DP  - 2009 Feb
TI  - Resident and "inflammatory" dendritic cells in human skin.
PG  - 302-8
LID - 10.1038/jid.2008.225 [doi]
AB  - Dendritic cells (DCs) are a heterogeneous group of antigen-presenting leukocytes 
      that are important in activation of both the innate and adaptive arms of the 
      immune system. Although there are several different DC populations in the body, 
      DCs are globally defined by their capacity for potent antigen presentation and 
      naive T-cell activation. In noninflamed human skin during steady state, there are 
      three main cutaneous DC populations: epidermal Langerhans cells, dermal myeloid 
      DCs, and dermal plasmacytoid DCs. In psoriasis, a model for cutaneous 
      inflammation, there is an additional population of myeloid dermal 
      DCs--"inflammatory DCs"--which appears to be critical for disease pathogenesis.
FAU - Zaba, Lisa C
AU  - Zaba LC
AD  - Laboratory for Investigative Dermatology, The Rockefeller University, New York, 
      New York 10065, USA.
FAU - Krueger, James G
AU  - Krueger JG
FAU - Lowes, Michelle A
AU  - Lowes MA
LA  - eng
GR  - 1 K23 AR052404-01A1/AR/NIAMS NIH HHS/United States
GR  - R01 AI049832/AI/NIAID NIH HHS/United States
GR  - UL1 RR024143/RR/NCRR NIH HHS/United States
GR  - K23 AR052404/AR/NIAMS NIH HHS/United States
GR  - T32 GM007739/GM/NIGMS NIH HHS/United States
GR  - R01 AI049572/AI/NIAID NIH HHS/United States
GR  - UL1 RR024143-027722/RR/NCRR NIH HHS/United States
GR  - GM07739/GM/NIGMS NIH HHS/United States
GR  - UL1 RR024143-035903/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20080814
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
SB  - IM
MH  - Dendritic Cells/*immunology/pathology
MH  - Dermatitis/*immunology/pathology
MH  - Humans
MH  - Skin/*immunology/pathology
PMC - PMC2746703
MID - NIHMS126276
COIS- Conflict Of Interest: The authors state no conflict of interest.
EDAT- 2008/08/08 09:00
MHDA- 2009/02/28 09:00
PMCR- 2009/09/18
CRDT- 2008/08/08 09:00
PHST- 2008/08/08 09:00 [pubmed]
PHST- 2009/02/28 09:00 [medline]
PHST- 2008/08/08 09:00 [entrez]
PHST- 2009/09/18 00:00 [pmc-release]
AID - S0022-202X(15)34204-4 [pii]
AID - 10.1038/jid.2008.225 [doi]
PST - ppublish
SO  - J Invest Dermatol. 2009 Feb;129(2):302-8. doi: 10.1038/jid.2008.225. Epub 2008 
      Aug 14.