PMID- 18686619
OWN - NLM
STAT- MEDLINE
DCOM- 20100528
LR  - 20131121
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 30
IP  - 3
DP  - 2008 Jun
TI  - [Effect of low-dose folate treatment on plasma homocystyeine and chemokine levels 
      in patients with hyperhomocysteinemia].
PG  - 342-3
AB  - OBJECTIVE: To explore the effect of low-dose folate on plasma homocysteinemia 
      (Hcy) and chemokine levels in patients with hyperhomocysteinemia (HHcy). METHODS: 
      Forty HHcy patients were treated with 0.8 mg/d folate for 6 months. Plasma levels 
      of Hcy, monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), 
      malondialdehyde (MDA), and superoxide dismutase (SOD) were measured before and 
      after folate treatment. RESULTS: Plasma level of Hcy significantly decreased 
      after folate treatment [(57.1 +/- 18.0) micromol/L vs (25.8 +/- 12.0) micromol/L, 
      P <0.05]. However, the plasma levels of MCP-1, IL-8, SOD, and MDA were not 
      changed after folate treatment. CONCLUSION: Folate treatment can decrease the 
      plasma Hcy level in HHcy patients; however, it has no obvious effects on the 
      chemokine levels.
FAU - Lu, Chang-Lin
AU  - Lu CL
AD  - Department of Cardiology, Tongren Hospital, Capital University of Medical 
      Sciences, Beijing 100730, China. cardiolucl@yahoo.com.cn
FAU - Wang, Guang
AU  - Wang G
FAU - Guo, Jing-Xuan
AU  - Guo JX
LA  - chi
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
RN  - 0 (Chemokines)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Aged
MH  - Chemokines/*blood
MH  - Female
MH  - Folic Acid/administration & dosage/*therapeutic use
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
EDAT- 2008/08/09 09:00
MHDA- 2010/05/29 06:00
CRDT- 2008/08/09 09:00
PHST- 2008/08/09 09:00 [pubmed]
PHST- 2010/05/29 06:00 [medline]
PHST- 2008/08/09 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008 Jun;30(3):342-3.