PMID- 18687323
OWN - NLM
STAT- MEDLINE
DCOM- 20090306
LR  - 20211020
IS  - 1095-564X (Electronic)
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 322
IP  - 2
DP  - 2008 Oct 15
TI  - Organ-specific requirements for Hdac1 in liver and pancreas formation.
PG  - 237-50
LID - 10.1016/j.ydbio.2008.06.040 [doi]
AB  - Liver, pancreas and lung originate from the presumptive foregut in temporal and 
      spatial proximity. This requires precisely orchestrated transcriptional 
      activation and repression of organ-specific gene expression within the same cell. 
      Here, we show distinct roles for the chromatin remodelling factor and 
      transcriptional repressor Histone deacetylase 1 (Hdac1) in endodermal 
      organogenesis in zebrafish. Loss of Hdac1 causes defects in timely liver 
      specification and in subsequent differentiation. Mosaic analyses reveal a 
      cell-autonomous requirement for hdac1 within the hepatic endoderm. Our studies 
      further reveal specific functions for Hdac1 in pancreas development. Loss of 
      hdac1 causes the formation of ectopic endocrine clusters anteriorly to the main 
      islet, as well as defects in exocrine pancreas specification and differentiation. 
      In addition, we observe defects in extrahepatopancreatic duct formation and 
      morphogenesis. Finally, loss of hdac1 results in an expansion of the foregut 
      endoderm in the domain from which the liver and pancreas originate. Our genetic 
      studies demonstrate that Hdac1 is crucial for regulating distinct steps in 
      endodermal organogenesis. This suggests a model in which Hdac1 may directly or 
      indirectly restrict foregut fates while promoting hepatic and exocrine pancreatic 
      specification and differentiation, as well as pancreatic endocrine islet 
      morphogenesis. These findings establish zebrafish as a tractable system to 
      investigate chromatin remodelling factor functions in controlling gene expression 
      programmes in vertebrate endodermal organogenesis.
FAU - Noel, Emily S
AU  - Noel ES
AD  - National Institute for Medical Research, Division of Developmental Biology, The 
      Ridgeway, Mill Hill, London, UK.
FAU - Casal-Sueiro, Antonio
AU  - Casal-Sueiro A
FAU - Busch-Nentwich, Elisabeth
AU  - Busch-Nentwich E
FAU - Verkade, Heather
AU  - Verkade H
FAU - Dong, P Duc Si
AU  - Dong PD
FAU - Stemple, Derek L
AU  - Stemple DL
FAU - Ober, Elke A
AU  - Ober EA
LA  - eng
GR  - MC_U117581329/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080721
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Zebrafish Proteins)
RN  - EC 3.5.1.98 (HDAC1 protein, zebrafish)
RN  - EC 3.5.1.98 (Histone Deacetylase 1)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Cell Proliferation
MH  - Endoderm/embryology
MH  - Hepatocytes/cytology/physiology
MH  - Histone Deacetylase 1
MH  - Histone Deacetylases/genetics/*metabolism
MH  - Liver/*embryology/enzymology
MH  - Lung/embryology/enzymology
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Organ Specificity
MH  - Pancreas/*embryology/enzymology
MH  - Zebrafish/*embryology/metabolism
MH  - Zebrafish Proteins/genetics/*metabolism
PMC - PMC3710974
EDAT- 2008/08/09 09:00
MHDA- 2009/03/07 09:00
PMCR- 2008/10/15
CRDT- 2008/08/09 09:00
PHST- 2008/01/10 00:00 [received]
PHST- 2008/05/28 00:00 [revised]
PHST- 2008/06/20 00:00 [accepted]
PHST- 2008/08/09 09:00 [pubmed]
PHST- 2009/03/07 09:00 [medline]
PHST- 2008/08/09 09:00 [entrez]
PHST- 2008/10/15 00:00 [pmc-release]
AID - S0012-1606(08)01020-8 [pii]
AID - 10.1016/j.ydbio.2008.06.040 [doi]
PST - ppublish
SO  - Dev Biol. 2008 Oct 15;322(2):237-50. doi: 10.1016/j.ydbio.2008.06.040. Epub 2008 
      Jul 21.