PMID- 18687756
OWN - NLM
STAT- MEDLINE
DCOM- 20080916
LR  - 20151119
IS  - 1465-3621 (Electronic)
IS  - 0368-2811 (Linking)
VI  - 38
IP  - 8
DP  - 2008 Aug
TI  - Follicular lymphoma of the duodenum: a clinicopathologic analysis of 26 cases.
PG  - 547-52
LID - 10.1093/jjco/hyn069 [doi]
AB  - OBJECTIVE: Follicular lymphomas (FLs) occur commonly in the lymph nodes, and 
      duodenal FL (DFL) is reported to be rare. METHODS: We analysed the clinical, 
      morphological, immunohistochemical and genetic features of 26 cases of DFL. 
      Primary DFLs and systemic FLs that involved the duodenum at any point during the 
      clinical course were included in the analysis. RESULTS: Typically, primary DFLs 
      (14 cases) were found incidentally at routine medical check-ups, whereas 
      involvement of the duodenum by systemic FLs (12 cases) was found through staging 
      procedures. All cases involved the second portion of the duodenum. Helicobacter 
      pylori infection was common (71%). In all cases, the histologic grade was low 
      (either grade 1 or 2), and CD20, CD10 and Bcl-2 were positive by 
      immunohistochemistry. Immunoglobulin heavy chain gene (IGH) and bcl-2 gene (BCL2) 
      fusion was frequently shown by fluorescence in situ hybridization (FISH) 
      analysis: nine of 12 cases (75%) of primary DFL and 10 of 12 cases (83%) of 
      systemic DFL were positive. Treatment regimens employed were rituximab (R) plus 
      chemotherapy (10), R (6), chemotherapy (3), irradiation (3) and the other three 
      patients were subjected to observation. After a median follow-up duration of 40 
      months (ranging 11-96 months), 17 patients were alive without disease, seven were 
      alive with disease and one had died of lymphoma. CONCLUSIONS: Primary DFLs 
      resemble systemic and nodal FLs, except that the former has high incidence of 
      early stage and low-grade histology. The duodenum appears to be a frequently 
      involved extranodal site of FL with IGH/BCL2.
FAU - Sentani, Kazuhiro
AU  - Sentani K
AD  - Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan.
FAU - Maeshima, Akiko Miyagi
AU  - Maeshima AM
FAU - Nomoto, Junko
AU  - Nomoto J
FAU - Maruyama, Dai
AU  - Maruyama D
FAU - Kim, Sung-Won
AU  - Kim SW
FAU - Watanabe, Takashi
AU  - Watanabe T
FAU - Kobayashi, Yukio
AU  - Kobayashi Y
FAU - Tobinai, Kensei
AU  - Tobinai K
FAU - Matsuno, Yoshihiro
AU  - Matsuno Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080807
PL  - England
TA  - Jpn J Clin Oncol
JT  - Japanese journal of clinical oncology
JID - 0313225
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - Duodenal Neoplasms/genetics/*pathology
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Follicular/genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/genetics/metabolism/therapy
MH  - Proto-Oncogene Proteins c-bcl-2/genetics
MH  - Survival Rate
EDAT- 2008/08/09 09:00
MHDA- 2008/09/17 09:00
CRDT- 2008/08/09 09:00
PHST- 2008/08/09 09:00 [pubmed]
PHST- 2008/09/17 09:00 [medline]
PHST- 2008/08/09 09:00 [entrez]
AID - hyn069 [pii]
AID - 10.1093/jjco/hyn069 [doi]
PST - ppublish
SO  - Jpn J Clin Oncol. 2008 Aug;38(8):547-52. doi: 10.1093/jjco/hyn069. Epub 2008 Aug 
      7.