PMID- 18689248
OWN - NLM
STAT- MEDLINE
DCOM- 20081010
LR  - 20131121
IS  - 0044-4677 (Print)
IS  - 0044-4677 (Linking)
VI  - 58
IP  - 3
DP  - 2008 May-Jun
TI  - [Effect of serotonin deficit at different stages of prenatal ontogenesis on 
      behavior of adult male and female rats].
PG  - 359-67
AB  - Effects of maternal parachlorophenilalanine (PCPA) administration on the 
      offspring behavior were studied in the open field, Porsolt forced swimming, and 
      Morris water maze tests. PCPA was administered in two different gestational 
      periods: on gestational days (GD) 8-11 or GD 14-17, at doses 200/100/100/50 
      mg/kg. It was found that prenatal exposure to PCPA results in fetal serotonin 
      (5-HT) depletion and changes in both open field activity and depression-related 
      behavior, as well as impairments in spatial learning in the adult offspring. The 
      most pronounced effects on behavior were observed in the male and female 
      offspring whose mothers were depleted of serotonin by PCPA during the third 
      trimester of pregnancy. These results provide further evidence that adverse 
      factors have the most severe effects on the development of rat brain function 
      when exposed during the final trimester of pregnancy than during the second 
      trimester.
FAU - Vataeva, L A
AU  - Vataeva LA
FAU - Kudrin, V S
AU  - Kudrin VS
FAU - Vershinina, E A
AU  - Vershinina EA
FAU - Mosin, V M
AU  - Mosin VM
FAU - Tiul'kova, E I
AU  - Tiul'kova EI
FAU - Otellin, V A
AU  - Otellin VA
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Zh Vyssh Nerv Deiat Im I P Pavlova
JT  - Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
JID - 9421551
RN  - 333DO1RDJY (Serotonin)
RN  - R5J7E3L9SP (Fenclonine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects/*physiology
MH  - Depression/*physiopathology
MH  - Female
MH  - Fenclonine/*pharmacology
MH  - Male
MH  - Motor Activity/drug effects/*physiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*physiopathology
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/*deficiency
EDAT- 2008/08/12 09:00
MHDA- 2008/10/11 09:00
CRDT- 2008/08/12 09:00
PHST- 2008/08/12 09:00 [pubmed]
PHST- 2008/10/11 09:00 [medline]
PHST- 2008/08/12 09:00 [entrez]
PST - ppublish
SO  - Zh Vyssh Nerv Deiat Im I P Pavlova. 2008 May-Jun;58(3):359-67.