PMID- 18689697
OWN - NLM
STAT- MEDLINE
DCOM- 20090116
LR  - 20240312
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 50
IP  - 1
DP  - 2009 Jan
TI  - Detection of optic nerve head neural canal opening within histomorphometric and 
      spectral domain optical coherence tomography data sets.
PG  - 214-23
LID - 10.1167/iovs.08-2302 [doi]
AB  - PURPOSE: To assess the ability to detect the neural canal opening (NCO) and its 
      characteristics within three-dimensional (3-D) histomorphometric and 3-D spectral 
      domain optical coherence tomography (SD-OCT) reconstructions of the optic nerve 
      head from nonhuman primate (NHP) eyes. METHODS: NCO was delineated within 40 
      radial, sagittal sections of 3-D histomorphometric reconstructions of 44 normal 
      eyes of 38 NHPs, each perfusion fixed at IOP 10 mm Hg, and 3-D SD-OCT 
      (Spectralis; Heidelberg Engineering, Heidelberg, Germany) volumes acquired in 
      vivo from a separate group of 33 normal eyes of 24 NHPs. Within all 
      reconstructions, a least-squares ellipse was fitted to the 80 NCO points. For 
      each eye, the dimensions and plane error (a gauge of planarity) of the fitted 
      ellipse were calculated. RESULTS: The NCO was successfully delineated within 
      every section of each histomorphometric and SD-OCT reconstruction. Median plane 
      error was similar within histomorphometric and SD-OCT volumes (8 microm, range 
      4-19, histomorphometry, and 10 microm, range 4-26, SD-OCT) and was small relative 
      to the size of the ellipse. Median histomorphometric ellipse dimensions were 1453 
      mum (major axis, range 1218-1737) and 1066 microm (minor axis, range 808-1263). 
      Median SD-OCT ellipse dimensions were 1512 microm (major axis, range 1191-1865) 
      and 1060 microm (minor axis, range 772-1248). CONCLUSIONS: The NCO is 
      biologically continuous and relatively planar within all 3-D histomorphometric 
      and SD-OCT reconstructions. These characteristics support its further evaluation 
      as a reference plane for cross-sectional and longitudinal measurement of optic 
      nerve head structures using 3-D SD-OCT.
FAU - Strouthidis, Nicholas G
AU  - Strouthidis NG
AD  - Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, 
      Portland, OR 97208-3950, USA.
FAU - Yang, Hongli
AU  - Yang H
FAU - Fortune, Brad
AU  - Fortune B
FAU - Downs, J Crawford
AU  - Downs JC
FAU - Burgoyne, Claude F
AU  - Burgoyne CF
LA  - eng
GR  - R01 EY011610/EY/NEI NIH HHS/United States
GR  - R01 EY011610-11/EY/NEI NIH HHS/United States
GR  - R01-EY11610/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080808
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Animals
MH  - *Axons
MH  - Female
MH  - Image Processing, Computer-Assisted
MH  - Imaging, Three-Dimensional/methods
MH  - Macaca fascicularis
MH  - Macaca mulatta
MH  - Male
MH  - Neural Tube/*anatomy & histology
MH  - Optic Disk/*anatomy & histology
MH  - Tomography, Optical Coherence/*methods
PMC - PMC2726821
MID - NIHMS118694
EDAT- 2008/08/12 09:00
MHDA- 2009/01/17 09:00
PMCR- 2010/01/01
CRDT- 2008/08/12 09:00
PHST- 2008/08/12 09:00 [pubmed]
PHST- 2009/01/17 09:00 [medline]
PHST- 2008/08/12 09:00 [entrez]
PHST- 2010/01/01 00:00 [pmc-release]
AID - iovs.08-2302 [pii]
AID - 10.1167/iovs.08-2302 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2009 Jan;50(1):214-23. doi: 10.1167/iovs.08-2302. Epub 
      2008 Aug 8.