PMID- 18689886
OWN - NLM
STAT- MEDLINE
DCOM- 20081112
LR  - 20211020
IS  - 0016-6731 (Print)
IS  - 0016-6731 (Linking)
VI  - 179
IP  - 4
DP  - 2008 Aug
TI  - Molecular cytogenetic evidence of rearrangements on the Y chromosome of the 
      threespine stickleback fish.
PG  - 2173-82
LID - 10.1534/genetics.108.088559 [doi]
AB  - To identify the processes shaping vertebrate sex chromosomes during the early 
      stages of their evolution, it is necessary to study systems in which genetic sex 
      determination was recently acquired. Previous cytogenetic studies suggested that 
      threespine stickleback fish (Gasterosteus aculeatus) do not have a heteromorphic 
      sex chromosome pair, although recent genetic studies found evidence of an XY 
      genetic sex-determination system. Using fluorescence in situ hybridization 
      (FISH), we report that the threespine stickleback Y chromosome is heteromorphic 
      and has suffered both inversions and deletion. Using the FISH data, we 
      reconstruct the rearrangements that have led to the current physical state of the 
      threespine stickleback Y chromosome. These data demonstrate that the threespine Y 
      is more degenerate than previously thought, suggesting that the process of sex 
      chromosome evolution can occur rapidly following acquisition of a sex-determining 
      region.
FAU - Ross, Joseph A
AU  - Ross JA
AD  - Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, 
      Washington 98101, USA.
FAU - Peichel, Catherine L
AU  - Peichel CL
LA  - eng
GR  - P50 HG-02568/HG/NHGRI NIH HHS/United States
GR  - T32 GM007270/GM/NIGMS NIH HHS/United States
GR  - R01 GM071854/GM/NIGMS NIH HHS/United States
GR  - T32 GM-07270/GM/NIGMS NIH HHS/United States
GR  - R01 GM-071854/GM/NIGMS NIH HHS/United States
GR  - P50 HG002568/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080809
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
SB  - IM
MH  - Animals
MH  - *Chromosome Deletion
MH  - *Chromosome Inversion
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Bacterial
MH  - Evolution, Molecular
MH  - Female
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Sex Determination Processes
MH  - Smegmamorpha/*genetics
MH  - *Y Chromosome
PMC - PMC2516089
EDAT- 2008/08/12 09:00
MHDA- 2008/11/13 09:00
PMCR- 2008/11/01
CRDT- 2008/08/12 09:00
PHST- 2008/08/12 09:00 [pubmed]
PHST- 2008/11/13 09:00 [medline]
PHST- 2008/08/12 09:00 [entrez]
PHST- 2008/11/01 00:00 [pmc-release]
AID - genetics.108.088559 [pii]
AID - gen17942173 [pii]
AID - 10.1534/genetics.108.088559 [doi]
PST - ppublish
SO  - Genetics. 2008 Aug;179(4):2173-82. doi: 10.1534/genetics.108.088559. Epub 2008 
      Aug 9.