PMID- 18690416
OWN - NLM
STAT- MEDLINE
DCOM- 20090421
LR  - 20220311
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 126
IP  - 1-3
DP  - 2008 Winter
TI  - Oxidative stress in migraine with and without aura.
PG  - 92-7
LID - 10.1007/s12011-008-8193-9 [doi]
AB  - Migraine is the most common neurological disorder, but the molecular basis is 
      still not completely understood. An impairment of mitochondrial oxidative 
      metabolism might play a role in the pathophysiology. The goal of this study was 
      to investigate the differences in oxidative stress status with the measurement of 
      erythrocyte superoxide dismutase (SOD), catalase activity, and malondialdehyde 
      (MDA) levels in the migraine patients with or without aura and attack. There were 
      56 patients (46 female, 10 male) in the migraine group and 25 matched healthy 
      subjects in the control group. The patients comprised 37 with migraine without 
      aura (MWoA], 19 with migraine with aura (MWA), and 22 with headache attack. The 
      MDA levels of patients in the migraine group were significantly higher than that 
      in the control group. The SOD activity was significantly higher in the MWA as 
      compared to MWoA. There was no significant correlation between these levels and 
      headache attack period. Conclusively, in this preliminary study, we had found 
      increased oxidative stress in the migraine patients especially the patients with 
      MWA. Further knowledge about this issue may contribute the cause and 
      complications of migraine and may be essential for development of treatment 
      approaches.
FAU - Tuncel, Deniz
AU  - Tuncel D
AD  - Department of Neurology, Faculty of Medicine, Kahramanmaras Sutcu Imam University 
      , Kahramanmaras, Turkey. tuncedeniz@yahoo.com
FAU - Tolun, Fatma Inanc
AU  - Tolun FI
FAU - Gokce, Mustafa
AU  - Gokce M
FAU - Imrek, Secil
AU  - Imrek S
FAU - Ekerbicer, Hasan
AU  - Ekerbicer H
LA  - eng
PT  - Journal Article
DEP - 20080809
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Catalase/blood/metabolism
MH  - Female
MH  - Humans
MH  - Lipid Peroxidation
MH  - Male
MH  - Malondialdehyde/blood/metabolism
MH  - Migraine with Aura/*blood/metabolism
MH  - Migraine without Aura/*blood/metabolism
MH  - Oxidative Stress/*physiology
MH  - Superoxide Dismutase/blood/metabolism
EDAT- 2008/08/12 09:00
MHDA- 2009/04/22 09:00
CRDT- 2008/08/12 09:00
PHST- 2008/06/16 00:00 [received]
PHST- 2008/06/27 00:00 [accepted]
PHST- 2008/08/12 09:00 [pubmed]
PHST- 2009/04/22 09:00 [medline]
PHST- 2008/08/12 09:00 [entrez]
AID - 10.1007/s12011-008-8193-9 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2008 Winter;126(1-3):92-7. doi: 10.1007/s12011-008-8193-9. 
      Epub 2008 Aug 9.