PMID- 18691136
OWN - NLM
STAT- MEDLINE
DCOM- 20090210
LR  - 20191111
IS  - 1871-5281 (Print)
IS  - 1871-5281 (Linking)
VI  - 7
IP  - 2
DP  - 2008 Jun
TI  - Intravenous immunoglobulin therapy in dermatologic disorders.
PG  - 75-84
AB  - Intravenous immunoglobulin (IVIG) is sterilized and purified human plasma which 
      contains supra-physiologic levels of immunoglobulin G. IVIG is currently used in 
      the treatment of immunodeficiency syndromes, inflammatory disorders and 
      infectious diseases. Although numerous immunomodulatory mechanisms have been 
      suggested, the exact mechanisms of action are poorly understood. There is also 
      accumulating evidence that high-dose IVIG is efficacious in the treatment of some 
      skin diseases, despite the lack of evidence from randomized, double-blind, 
      placebo-controlled trials. Though in most cases, IVIG is only effective in 
      combination with other immunomodulating strategies, it offers new hope for the 
      treatment of many severe dermatologic conditions. This article focuses on the 
      efficacy and safety of IVIG therapy in skin diseases.
FAU - Cakmak, Seray Kulcu
AU  - Cakmak SK
AD  - Turan Gunes Bulvari 71, Sokak 18/8 Yildiz, Cankaya, Ankara, Turkey. 
      seraycakmak@yahoo.com
FAU - Gul, Ulker
AU  - Gul U
FAU - Gonul, Muzeyyen
AU  - Gonul M
FAU - Kilic, Arzu
AU  - Kilic A
FAU - Soylu, Secil
AU  - Soylu S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Inflamm Allergy Drug Targets
JT  - Inflammation & allergy drug targets
JID - 101266886
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Autoimmune Diseases/immunology/*therapy
MH  - Drug Administration Routes
MH  - Humans
MH  - *Immunization, Passive
MH  - Immunoglobulins, Intravenous/administration & dosage/adverse 
      effects/immunology/*therapeutic use
MH  - Skin Diseases/*immunology/*therapy
RF  - 114
EDAT- 2008/08/12 09:00
MHDA- 2009/02/12 09:00
CRDT- 2008/08/12 09:00
PHST- 2008/08/12 09:00 [pubmed]
PHST- 2009/02/12 09:00 [medline]
PHST- 2008/08/12 09:00 [entrez]
AID - 10.2174/187152808785107651 [doi]
PST - ppublish
SO  - Inflamm Allergy Drug Targets. 2008 Jun;7(2):75-84. doi: 
      10.2174/187152808785107651.