PMID- 18692116
OWN - NLM
STAT- MEDLINE
DCOM- 20090203
LR  - 20131121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 443
IP  - 3
DP  - 2008 Oct 10
TI  - The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is not 
      significantly correlated to Transient Global Amnesia: preliminary results of an 
      on-going study in Brescia Province, Italy.
PG  - 228-31
LID - 10.1016/j.neulet.2008.07.082 [doi]
AB  - Transient Global Amnesia (TGA) is a well defined pure amnesic clinical syndrome 
      characterized by acute loss of memory in middle aged people. The aetiology of TGA 
      is still unknown but clinical and neuroimaging studies support a hippocampi 
      involvement, and some reports suggested a possible common genetic background in 
      cases of familial TGA. A single nucleotide polymorphism (SNP) in the 
      Brain-derived neurotrophic factor (BDNF) gene that causes a valine to methionine 
      substitution at codon 66 (Val66Met) has been demonstrated to affect human memory 
      and hippocampal function in the development and maintenance of adult neurons. Aim 
      of this study was to evaluate the role of BDNF Val66Met polymorphism on TGA risk 
      and all TGA clinical features. Ninety-eight TGA patients and 93 age-matched 
      controls were enrolled in the study. Each patient underwent clinical and 
      neurological examination, routine blood examination, EEG, Jugular vein valve 
      (JVI) competence assessment, and neuroimaging study. TGA characteristics were 
      carefully recorded. The distribution of BDNF genotype did not differ in TGA 
      patients compared to controls (BDNF GG: 58.2% vs 55.9%, GA: 33.7% vs 36.6%, AA: 
      8.1% vs 7.5%, P=.91) as well as allele frequency (BDNF G, TGA vs CON: 75.0% vs 
      74.2, P=.47). No significant differences in age at onset, disease duration and 
      recurrence or the presence of predisposing factors between TGA patients carrying 
      BDNF AA, BDNF GA and BDNF GG genotype were found. This study, that firstly looked 
      at genetic background in TGA, did not show a significant correlation between the 
      BDNF Val66Met polymorphism and age of onset, risk factors, duration or recurrence 
      of TGA.
FAU - Agosti, C
AU  - Agosti C
AD  - Department of Neurology, University of Brescia, Italy.
FAU - Borroni, B
AU  - Borroni B
FAU - Archetti, S
AU  - Archetti S
FAU - Akkawi, N M
AU  - Akkawi NM
FAU - Padovani, A
AU  - Padovani A
LA  - eng
PT  - Journal Article
DEP - 20080803
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Aged
MH  - Amnesia, Transient Global/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Italy
MH  - Male
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Valine/*genetics
EDAT- 2008/08/12 09:00
MHDA- 2009/02/04 09:00
CRDT- 2008/08/12 09:00
PHST- 2008/04/15 00:00 [received]
PHST- 2008/07/29 00:00 [revised]
PHST- 2008/07/30 00:00 [accepted]
PHST- 2008/08/12 09:00 [pubmed]
PHST- 2009/02/04 09:00 [medline]
PHST- 2008/08/12 09:00 [entrez]
AID - S0304-3940(08)01077-X [pii]
AID - 10.1016/j.neulet.2008.07.082 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Oct 10;443(3):228-31. doi: 10.1016/j.neulet.2008.07.082. Epub 
      2008 Aug 3.