PMID- 18692438
OWN - NLM
STAT- MEDLINE
DCOM- 20090127
LR  - 20151119
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 10
IP  - 9
DP  - 2008 Sep
TI  - Gender-specific differences in left ventricular remodelling and fibrosis in 
      hypertrophic cardiomyopathy: insights from cardiovascular magnetic resonance.
PG  - 850-4
LID - 10.1016/j.ejheart.2008.06.021 [doi]
AB  - BACKGROUND: Gender is an independent risk factor for heart failure mortality in 
      hypertrophic cardiomyopathy (HCM). AIMS: To explore the interaction between 
      gender, myocardial fibrosis and remodelling in HCM. METHODS: We studied 64 HCM 
      patients (28 females, aged 51+/-16 years) categorized as non-obstructive (HNCM, 
      n=31) or obstructive (HOCM, n=33) and 60 healthy subjects (31 females, aged 
      43+/-14 years). Cine imaging was performed to assess left ventricular volumes and 
      mass. LV remodelling index (LVRI) was calculated. Extension of late gadolinium 
      enhancement (LGE) was quantified. RESULTS: Females in the control group and in 
      the HNCM group had a lower LVRI than males (control: 0.7+/-0.1 vs. 0.9+/-0.2 
      g/ml, p<0.002; HNCM: 1.1+/-0.2 vs. 1.5+/-0.5 g/ml, p<0.001). In contrast, HOCM 
      females had a similar LVRI compared to males (1.8+/-0.5 vs. 1.7+/-0.4 g/ml, 
      p=ns). Thus the increase in LVRI was more pronounced in females compared to 
      males. LGE was noted in 70% of the patients. No relation was found between the 
      presence or the quantity of myocardial fibrosis and gender in any of the patient 
      subgroups. CONCLUSION: Our data suggest a disproportionate degree of remodelling 
      in different forms of HCM depending on gender. Gender does not appear to 
      influence the quantity of fibrosis as defined by LGE.
FAU - Schulz-Menger, Jeanette
AU  - Schulz-Menger J
AD  - Franz-Volhard-Klinik, Kardiologie, Charite Campus Buch, HELIOS-Klinikum Berlin, 
      Universitatsmedizin Berlin, Germany. jeanette.schulz-menger@charite.de
FAU - Abdel-Aty, Hassan
AU  - Abdel-Aty H
FAU - Rudolph, Andre
AU  - Rudolph A
FAU - Elgeti, Thomas
AU  - Elgeti T
FAU - Messroghli, Daniel
AU  - Messroghli D
FAU - Utz, Wolfgang
AU  - Utz W
FAU - Boye, Philipp
AU  - Boye P
FAU - Bohl, Steffen
AU  - Bohl S
FAU - Busjahn, Andreas
AU  - Busjahn A
FAU - Hamm, Bernd
AU  - Hamm B
FAU - Dietz, Rainer
AU  - Dietz R
LA  - eng
PT  - Journal Article
DEP - 20080809
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Analysis of Variance
MH  - Cardiomyopathy, Hypertrophic/*physiopathology
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Female
MH  - Fibrosis/physiopathology
MH  - Gadolinium DTPA
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Ventricular Remodeling/*physiology
EDAT- 2008/08/12 09:00
MHDA- 2009/01/28 09:00
CRDT- 2008/08/12 09:00
PHST- 2007/11/16 00:00 [received]
PHST- 2008/04/23 00:00 [revised]
PHST- 2008/06/09 00:00 [accepted]
PHST- 2008/08/12 09:00 [pubmed]
PHST- 2009/01/28 09:00 [medline]
PHST- 2008/08/12 09:00 [entrez]
AID - S1388-9842(08)00294-8 [pii]
AID - 10.1016/j.ejheart.2008.06.021 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2008 Sep;10(9):850-4. doi: 10.1016/j.ejheart.2008.06.021. Epub 
      2008 Aug 9.